Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Study of the Penetration of a Monoclonal Antibody Combination (ASN100) Targeting Staphylococcus aureus Cytotoxins in the Lung Epithelial Lining Fluid of Healthy Volunteers

ASN100 is a novel antibody combination of two fully human IgG1(κ) monoclonal antibodies (MAbs), ASN-1 and ASN-2, which neutralize six Staphylococcus aureus cytotoxins, alpha-hemolysin (Hla) and five bicomponent leukocidins. We assessed the safety, tolerability, and serum and lung pharmacokinetics of...

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Detalles Bibliográficos
Autores principales: Magyarics, Zoltan, Leslie, Fraser, Bartko, Johann, Rouha, Harald, Luperchio, Steven, Schörgenhofer, Christian, Schwameis, Michael, Derhaschnig, Ulla, Lagler, Heimo, Stiebellehner, Leopold, Firbas, Christa, Weber, Susanne, Campanaro, Ed, Jilma, Bernd, Nagy, Eszter, Stevens, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658777/
https://www.ncbi.nlm.nih.gov/pubmed/31138568
http://dx.doi.org/10.1128/AAC.00350-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658777/
https://www.ncbi.nlm.nih.gov/pubmed/31138568
http://dx.doi.org/10.1128/AAC.00350-19

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