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Regulated hAAT Expression from a Novel rAAV Vector and Its Application in the Prevention of Type 1 Diabetes

We, and others, have previously achieved high and sustained levels of transgene expression from viral vectors, such as recombinant adeno-associated virus (rAAV). However, regulatable transgene expression may be preferred in gene therapy for diseases, such as type 1 diabetes (T1D) and rheumatoid arth...

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Detalles Bibliográficos
Autores principales: Ma, Hongxia, Lu, Yuanqing, Lowe, Keith, van der Meijden-Erkelens, Lonneke, Wasserfall, Clive, Atkinson, Mark A., Song, Sihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6780368/
https://www.ncbi.nlm.nih.gov/pubmed/31466263
http://dx.doi.org/10.3390/jcm8091321