Caspase‐3‐mediated GSDME activation contributes to cisplatin‐ and doxorubicin‐induced secondary necrosis in mouse macrophages

OBJECTIVE: Induction of secondary necrosis/pyroptosis contributes to the toxicity of chemotherapeutic drugs, in which gasdermin E (GSDME) plays critical roles. This study aimed to explore whether GSDME is involved in mediating the cytotoxic effects of cisplatin and doxorubicin on mouse macrophages....

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Detalles Bibliográficos
Autores principales: Mai, Feng‐Yi, He, Pengyan, Ye, Jie‐Zhou, Xu, Li‐Hui, Ouyang, Dong‐Yun, Li, Chen‐Guang, Zeng, Qiong‐Zhen, Zeng, Chen‐Ying, Zhang, Cheng‐Cheng, He, Xian‐Hui, Hu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797504/
https://www.ncbi.nlm.nih.gov/pubmed/31347748
http://dx.doi.org/10.1111/cpr.12663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797504/
https://www.ncbi.nlm.nih.gov/pubmed/31347748
http://dx.doi.org/10.1111/cpr.12663

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