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Simultaneous measurement of p53:Mdm2 and p53:Mdm4 protein-protein interactions in whole cells using fluorescence labelled foci

In this report we describe the development of a Fluorescent Protein-Protein Interaction-visualization (FLUOPPI) to enable the simultaneous measurement of both Mdm2:p53 and Mdm4:p53 interactions in order to assess the relative efficiencies of mimetic molecules of the p53 peptide helix against both PP...

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Detalles Bibliográficos
Autores principales: Frosi, Y., Inoue, K., Ramlan, Siti Radhiah, Lane, D. P., Watanabe, T., Brown, C. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884555/
https://www.ncbi.nlm.nih.gov/pubmed/31784573
http://dx.doi.org/10.1038/s41598-019-54123-z