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Thioridazine Induces Cardiotoxicity via Reactive Oxygen Species-Mediated hERG Channel Deficiency and L-Type Calcium Channel Activation

Thioridazine (THIO) is a phenothiazine derivative that is mainly used for the treatment of psychotic disorders. However, cardiac arrhythmias especially QT interval prolongation associated with the application of this compound have received serious attention after its introduction into clinical pract...

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Detalles Bibliográficos
Autores principales: Liu, Yan, Xu, Xueqi, Zhang, Yuhao, Li, Mingzhu, Guo, Jiamengyi, Yan, Caichuan, Wang, Fang, Li, Yuexin, Ding, Yunqi, Li, Baoxin, Fan, Pan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998749/
https://www.ncbi.nlm.nih.gov/pubmed/32064022
http://dx.doi.org/10.1155/2020/3690123