PRMT7 deficiency causes dysregulation of the HCN channels in the CA1 pyramidal cells and impairment of social behaviors

HCN channels regulate excitability and rhythmicity in the hippocampal CA1 pyramidal cells. Perturbation in the HCN channel current (I(h)) is associated with neuropsychiatric disorders, such as autism spectrum disorders. Recently, protein arginine methyltransferase 7 (PRMT7) was shown to be highly ex...

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Detalles Bibliográficos
Autores principales: Lee, Seul-Yi, Vuong, Tuan Anh, So, Hyun-Kyung, Kim, Hyun-Ji, Bin Kim, Yoo, Kang, Jong-Sun, Kwon, Ilmin, Cho, Hana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210990/
https://www.ncbi.nlm.nih.gov/pubmed/32269286
http://dx.doi.org/10.1038/s12276-020-0417-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210990/
https://www.ncbi.nlm.nih.gov/pubmed/32269286
http://dx.doi.org/10.1038/s12276-020-0417-x

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