Cargando…

Duplex DNA engagement and RPA oppositely regulate the DNA-unwinding rate of CMG helicase

A ring-shaped helicase unwinds DNA during chromosome replication in all organisms. Replicative helicases generally unwind duplex DNA an order of magnitude slower compared to their in vivo replication fork rates. However, the origin of slow DNA unwinding rates by replicative helicases and the mechani...

Descripción completa

Detalles Bibliográficos
Autores principales: Kose, Hazal B., Xie, Sherry, Cameron, George, Strycharska, Melania S., Yardimci, Hasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382467/
https://www.ncbi.nlm.nih.gov/pubmed/32709841
http://dx.doi.org/10.1038/s41467-020-17443-7