Impact of single-heterozygous UGT1A1 on the clinical outcomes of irinotecan monotherapy after fluoropyrimidine and platinum-based combination therapy for gastric cancer: a multicenter retrospective study

BACKGROUND: It is unclear whether the UGT1A1 status, single heterozygous (SH) or wild type (WT), is associated with the efficacy and toxicity of irinotecan monotherapy in advanced gastric cancer (AGC). We investigated the association between clinical outcomes (efficacy and safety) and UGT1A1 status...

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Detalles Bibliográficos
Autores principales: Nakano, Shintaro, Yuki, Satoshi, Kawamoto, Yasuyuki, Nakatsumi, Hiroshi, Ando, Takayuki, Kajiura, Shinya, Yoshikawa, Ayumu, Harada, Kazuaki, Hatanaka, Kazuteru, Tanimoto, Aya, Ishiguro, Atsushi, Honda, Takuya, Dazai, Masayoshi, Sasaki, Takahide, Sakamoto, Naoya, Komatsu, Yoshito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498487/
https://www.ncbi.nlm.nih.gov/pubmed/32666389
http://dx.doi.org/10.1007/s10147-020-01720-y

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