Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling

Smoothened (SMO), a class-Frizzled G protein-coupled receptor (class-F GPCR), transduces the Hedgehog signal across cell membrane. Sterols can bind to its extracellular cysteine rich domain (CRD) and to several sites in the 7 transmembrane helices (7-TMs) of SMO. However, the mechanism how sterols r...

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Detalles Bibliográficos
Autores principales: Qi, Xiaofeng, Friedberg, Lucas, DeBose-Boyd, Ryan, Long, Tao, Li, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669734/
https://www.ncbi.nlm.nih.gov/pubmed/32929279
http://dx.doi.org/10.1038/s41589-020-0646-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669734/
https://www.ncbi.nlm.nih.gov/pubmed/32929279
http://dx.doi.org/10.1038/s41589-020-0646-2

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