PDX models reflect the proteome landscape of pediatric acute lymphoblastic leukemia but divert in select pathways

BACKGROUND: Murine xenografts of pediatric leukemia accurately recapitulate genomic aberrations. How this translates to the functional capacity of cells remains unclear. Here, we studied global protein abundance, phosphorylation, and protein maturation by proteolytic processing in 11 pediatric B- an...

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Detalles Bibliográficos
Autores principales: Uzozie, Anuli C., Ergin, Enes K., Rolf, Nina, Tsui, Janice, Lorentzian, Amanda, Weng, Samuel S. H., Nierves, Lorenz, Smith, Theodore G., Lim, C. James, Maxwell, Christopher A., Reid, Gregor S. D., Lange, Philipp F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958471/
https://www.ncbi.nlm.nih.gov/pubmed/33722259
http://dx.doi.org/10.1186/s13046-021-01835-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7958471/
https://www.ncbi.nlm.nih.gov/pubmed/33722259
http://dx.doi.org/10.1186/s13046-021-01835-8

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