Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network

The noradrenaline and dopamine reuptake inhibitor bupropion is metabolized by CYP2B6 and recommended by the FDA as the only sensitive substrate for clinical CYP2B6 drug–drug interaction (DDI) studies. The aim of this study was to build a whole-body physiologically based pharmacokinetic (PBPK) model...

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Detalles Bibliográficos
Autores principales: Marok, Fatima Zahra, Fuhr, Laura Maria, Hanke, Nina, Selzer, Dominik, Lehr, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001859/
https://www.ncbi.nlm.nih.gov/pubmed/33806634
http://dx.doi.org/10.3390/pharmaceutics13030331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001859/
https://www.ncbi.nlm.nih.gov/pubmed/33806634
http://dx.doi.org/10.3390/pharmaceutics13030331

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