Association of Major Dietary Protein Sources With All‐Cause and Cause‐Specific Mortality: Prospective Cohort Study

BACKGROUND: Dietary recommendations regarding protein intake have been focused on the amount of protein. However, such recommendations without considering specific protein sources may be simplistic and insufficient. METHODS AND RESULTS: We included 102 521 postmenopausal women enrolled in the Women’...

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Autores principales: Sun, Yangbo, Liu, Buyun, Snetselaar, Linda G., Wallace, Robert B., Shadyab, Aladdin H., Kroenke, Candyce H., Haring, Bernhard, Howard, Barbara V., Shikany, James M., Valdiviezo, Carolina, Bao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174240/
https://www.ncbi.nlm.nih.gov/pubmed/33624505
http://dx.doi.org/10.1161/JAHA.119.015553
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author Sun, Yangbo
Liu, Buyun
Snetselaar, Linda G.
Wallace, Robert B.
Shadyab, Aladdin H.
Kroenke, Candyce H.
Haring, Bernhard
Howard, Barbara V.
Shikany, James M.
Valdiviezo, Carolina
Bao, Wei
author_facet Sun, Yangbo
Liu, Buyun
Snetselaar, Linda G.
Wallace, Robert B.
Shadyab, Aladdin H.
Kroenke, Candyce H.
Haring, Bernhard
Howard, Barbara V.
Shikany, James M.
Valdiviezo, Carolina
Bao, Wei
author_sort Sun, Yangbo
collection PubMed
description BACKGROUND: Dietary recommendations regarding protein intake have been focused on the amount of protein. However, such recommendations without considering specific protein sources may be simplistic and insufficient. METHODS AND RESULTS: We included 102 521 postmenopausal women enrolled in the Women’s Health Initiative between 1993 and 1998, and followed them through February 2017. During 1 876 205 person‐years of follow‐up, 25 976 deaths occurred. Comparing the highest with the lowest quintile, plant protein intake was inversely associated with all‐cause mortality (hazard ratio [HR], 0.91 [0.86, 0.96]), cardiovascular disease mortality (HR, 0.88 [0.79, 0.97]), and dementia mortality (HR, 0.79 [0.67, 0.94]). Among major protein sources, comparing the highest with the lowest quintile of consumption, processed red meat (HR, 1.06 [1.01, 1.10]) or eggs (HR, 1.14 [1.10, 1.19]) was associated with higher risk of all‐cause mortality. Unprocessed red meat (HR, 1.12 [1.02, 1.23]), eggs (HR, 1.24 [1.14, 1.34]), or dairy products (HR, 1.11 [1.02, 1.22]) was associated with higher risk of cardiovascular disease mortality. Egg consumption was associated with higher risk of cancer mortality (HR, 1.10 [1.02, 1.19]). Processed red meat consumption was associated with higher risk of dementia mortality (HR, 1.20 [1.05, 1.32]), while consumption of poultry (HR, 0.85 [0.75, 0.97]) or eggs (HR, 0.86 [0.75, 0.98]) was associated with lower risk of dementia mortality. In substitution analysis, substituting of animal protein with plant protein was associated with a lower risk of all‐cause mortality, cardiovascular disease mortality, and dementia mortality, and substitution of total red meat, eggs, or dairy products with nuts was associated with a lower risk of all‐cause mortality. CONCLUSIONS: Different dietary protein sources have varying associations with all‐cause mortality, cardiovascular disease mortality, and dementia mortality. Our findings support the need for consideration of protein sources in future dietary guidelines.
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spelling pubmed-81742402021-06-11 Association of Major Dietary Protein Sources With All‐Cause and Cause‐Specific Mortality: Prospective Cohort Study Sun, Yangbo Liu, Buyun Snetselaar, Linda G. Wallace, Robert B. Shadyab, Aladdin H. Kroenke, Candyce H. Haring, Bernhard Howard, Barbara V. Shikany, James M. Valdiviezo, Carolina Bao, Wei J Am Heart Assoc Original Research BACKGROUND: Dietary recommendations regarding protein intake have been focused on the amount of protein. However, such recommendations without considering specific protein sources may be simplistic and insufficient. METHODS AND RESULTS: We included 102 521 postmenopausal women enrolled in the Women’s Health Initiative between 1993 and 1998, and followed them through February 2017. During 1 876 205 person‐years of follow‐up, 25 976 deaths occurred. Comparing the highest with the lowest quintile, plant protein intake was inversely associated with all‐cause mortality (hazard ratio [HR], 0.91 [0.86, 0.96]), cardiovascular disease mortality (HR, 0.88 [0.79, 0.97]), and dementia mortality (HR, 0.79 [0.67, 0.94]). Among major protein sources, comparing the highest with the lowest quintile of consumption, processed red meat (HR, 1.06 [1.01, 1.10]) or eggs (HR, 1.14 [1.10, 1.19]) was associated with higher risk of all‐cause mortality. Unprocessed red meat (HR, 1.12 [1.02, 1.23]), eggs (HR, 1.24 [1.14, 1.34]), or dairy products (HR, 1.11 [1.02, 1.22]) was associated with higher risk of cardiovascular disease mortality. Egg consumption was associated with higher risk of cancer mortality (HR, 1.10 [1.02, 1.19]). Processed red meat consumption was associated with higher risk of dementia mortality (HR, 1.20 [1.05, 1.32]), while consumption of poultry (HR, 0.85 [0.75, 0.97]) or eggs (HR, 0.86 [0.75, 0.98]) was associated with lower risk of dementia mortality. In substitution analysis, substituting of animal protein with plant protein was associated with a lower risk of all‐cause mortality, cardiovascular disease mortality, and dementia mortality, and substitution of total red meat, eggs, or dairy products with nuts was associated with a lower risk of all‐cause mortality. CONCLUSIONS: Different dietary protein sources have varying associations with all‐cause mortality, cardiovascular disease mortality, and dementia mortality. Our findings support the need for consideration of protein sources in future dietary guidelines. John Wiley and Sons Inc. 2021-02-24 /pmc/articles/PMC8174240/ /pubmed/33624505 http://dx.doi.org/10.1161/JAHA.119.015553 Text en © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Sun, Yangbo
Liu, Buyun
Snetselaar, Linda G.
Wallace, Robert B.
Shadyab, Aladdin H.
Kroenke, Candyce H.
Haring, Bernhard
Howard, Barbara V.
Shikany, James M.
Valdiviezo, Carolina
Bao, Wei
Association of Major Dietary Protein Sources With All‐Cause and Cause‐Specific Mortality: Prospective Cohort Study
title Association of Major Dietary Protein Sources With All‐Cause and Cause‐Specific Mortality: Prospective Cohort Study
title_full Association of Major Dietary Protein Sources With All‐Cause and Cause‐Specific Mortality: Prospective Cohort Study
title_fullStr Association of Major Dietary Protein Sources With All‐Cause and Cause‐Specific Mortality: Prospective Cohort Study
title_full_unstemmed Association of Major Dietary Protein Sources With All‐Cause and Cause‐Specific Mortality: Prospective Cohort Study
title_short Association of Major Dietary Protein Sources With All‐Cause and Cause‐Specific Mortality: Prospective Cohort Study
title_sort association of major dietary protein sources with all‐cause and cause‐specific mortality: prospective cohort study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8174240/
https://www.ncbi.nlm.nih.gov/pubmed/33624505
http://dx.doi.org/10.1161/JAHA.119.015553
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