Phenotypic manifestation of α-synuclein strains derived from Parkinson’s disease and multiple system atrophy in human dopaminergic neurons

α-Synuclein is critical in the pathogenesis of Parkinson’s disease and related disorders, yet it remains unclear how its aggregation causes degeneration of human dopaminergic neurons. In this study, we induced α-synuclein aggregation in human iPSC-derived dopaminergic neurons using fibrils generated...

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Detalles Bibliográficos
Autores principales: Tanudjojo, Benedict, Shaikh, Samiha S., Fenyi, Alexis, Bousset, Luc, Agarwal, Devika, Marsh, Jade, Zois, Christos, Heman-Ackah, Sabrina, Fischer, Roman, Sims, David, Melki, Ronald, Tofaris, George K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217249/
https://www.ncbi.nlm.nih.gov/pubmed/34155194
http://dx.doi.org/10.1038/s41467-021-23682-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217249/
https://www.ncbi.nlm.nih.gov/pubmed/34155194
http://dx.doi.org/10.1038/s41467-021-23682-z

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