Mouse Models of Germinal Center Derived B-Cell Lymphomas
Over the last decades, the revolution in DNA sequencing has changed the way we understand the genetics and biology of B-cell lymphomas by uncovering a large number of recurrently mutated genes, whose aberrant function is likely to play an important role in the initiation and/or maintenance of these...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387591/ https://www.ncbi.nlm.nih.gov/pubmed/34456919 http://dx.doi.org/10.3389/fimmu.2021.710711 |
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author | Meyer, Stefanie N. Koul, Sanjay Pasqualucci, Laura |
author_facet | Meyer, Stefanie N. Koul, Sanjay Pasqualucci, Laura |
author_sort | Meyer, Stefanie N. |
collection | PubMed |
description | Over the last decades, the revolution in DNA sequencing has changed the way we understand the genetics and biology of B-cell lymphomas by uncovering a large number of recurrently mutated genes, whose aberrant function is likely to play an important role in the initiation and/or maintenance of these cancers. Dissecting how the involved genes contribute to the physiology and pathology of germinal center (GC) B cells –the origin of most B-cell lymphomas– will be key to advance our ability to diagnose and treat these patients. Genetically engineered mouse models (GEMM) that faithfully recapitulate lymphoma-associated genetic alterations offer a valuable platform to investigate the pathogenic roles of candidate oncogenes and tumor suppressors in vivo, and to pre-clinically develop new therapeutic principles in the context of an intact tumor immune microenvironment. In this review, we provide a summary of state-of-the art GEMMs obtained by accurately modelling the most common genetic alterations found in human GC B cell malignancies, with a focus on Burkitt lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma, and we discuss how lessons learned from these models can help guide the design of novel therapeutic approaches for this disease. |
format | Online Article Text |
id | pubmed-8387591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83875912021-08-27 Mouse Models of Germinal Center Derived B-Cell Lymphomas Meyer, Stefanie N. Koul, Sanjay Pasqualucci, Laura Front Immunol Immunology Over the last decades, the revolution in DNA sequencing has changed the way we understand the genetics and biology of B-cell lymphomas by uncovering a large number of recurrently mutated genes, whose aberrant function is likely to play an important role in the initiation and/or maintenance of these cancers. Dissecting how the involved genes contribute to the physiology and pathology of germinal center (GC) B cells –the origin of most B-cell lymphomas– will be key to advance our ability to diagnose and treat these patients. Genetically engineered mouse models (GEMM) that faithfully recapitulate lymphoma-associated genetic alterations offer a valuable platform to investigate the pathogenic roles of candidate oncogenes and tumor suppressors in vivo, and to pre-clinically develop new therapeutic principles in the context of an intact tumor immune microenvironment. In this review, we provide a summary of state-of-the art GEMMs obtained by accurately modelling the most common genetic alterations found in human GC B cell malignancies, with a focus on Burkitt lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma, and we discuss how lessons learned from these models can help guide the design of novel therapeutic approaches for this disease. Frontiers Media S.A. 2021-08-12 /pmc/articles/PMC8387591/ /pubmed/34456919 http://dx.doi.org/10.3389/fimmu.2021.710711 Text en Copyright © 2021 Meyer, Koul and Pasqualucci https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Meyer, Stefanie N. Koul, Sanjay Pasqualucci, Laura Mouse Models of Germinal Center Derived B-Cell Lymphomas |
title | Mouse Models of Germinal Center Derived B-Cell Lymphomas |
title_full | Mouse Models of Germinal Center Derived B-Cell Lymphomas |
title_fullStr | Mouse Models of Germinal Center Derived B-Cell Lymphomas |
title_full_unstemmed | Mouse Models of Germinal Center Derived B-Cell Lymphomas |
title_short | Mouse Models of Germinal Center Derived B-Cell Lymphomas |
title_sort | mouse models of germinal center derived b-cell lymphomas |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387591/ https://www.ncbi.nlm.nih.gov/pubmed/34456919 http://dx.doi.org/10.3389/fimmu.2021.710711 |
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