Effects of 1α,25-Dihydroxyvitamin D(3) on the Pharmacokinetics of Procainamide and Its Metabolite N-Acetylprocainamide, Organic Cation Transporter Substrates, in Rats with PBPK Modeling Approach

In this study, possible changes in the expression of rat organic cationic transporters (rOCTs) and rat multidrug and toxin extrusion proteins (rMATEs) following treatment with 1α,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) were investigated. Rats received intraperitoneal administrations of 1,25(OH)(2...

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Detalles Bibliográficos
Autores principales: Balla, Anusha, Jeong, Yoo-Seong, Kim, Hyo-Jung, Lee, Yun-Jong, Chung, Suk-Jae, Chae, Yoon-Jee, Maeng, Han-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402143/
https://www.ncbi.nlm.nih.gov/pubmed/34452094
http://dx.doi.org/10.3390/pharmaceutics13081133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402143/
https://www.ncbi.nlm.nih.gov/pubmed/34452094
http://dx.doi.org/10.3390/pharmaceutics13081133

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