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Biosensors for Studying Neuronal Proteostasis

Cellular health depends on the integrity and functionality of the proteome. Each cell is equipped with a protein quality control machinery that maintains protein homeostasis (proteostasis) by helping proteins adopt and keep their native structure, and ensuring the degradation of damaged proteins. Po...

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Detalles Bibliográficos
Autor principal: Dudanova, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957107/
https://www.ncbi.nlm.nih.gov/pubmed/35345600
http://dx.doi.org/10.3389/fnmol.2022.829365
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author Dudanova, Irina
author_facet Dudanova, Irina
author_sort Dudanova, Irina
collection PubMed
description Cellular health depends on the integrity and functionality of the proteome. Each cell is equipped with a protein quality control machinery that maintains protein homeostasis (proteostasis) by helping proteins adopt and keep their native structure, and ensuring the degradation of damaged proteins. Postmitotic cells such as neurons are especially vulnerable to disturbances of proteostasis. Defects of protein quality control occur in aging and have been linked to several disorders, including neurodegenerative diseases. However, the exact nature and time course of such disturbances in the context of brain diseases remain poorly understood. Sensors that allow visualization and quantitative analysis of proteostasis capacity in neurons are essential for gaining a better understanding of disease mechanisms and for testing potential therapies. Here, I provide an overview of available biosensors for assessing the functionality of the neuronal proteostasis network, point out the advantages and limitations of different sensors, and outline their potential for biological discoveries and translational applications.
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spelling pubmed-89571072022-03-27 Biosensors for Studying Neuronal Proteostasis Dudanova, Irina Front Mol Neurosci Molecular Neuroscience Cellular health depends on the integrity and functionality of the proteome. Each cell is equipped with a protein quality control machinery that maintains protein homeostasis (proteostasis) by helping proteins adopt and keep their native structure, and ensuring the degradation of damaged proteins. Postmitotic cells such as neurons are especially vulnerable to disturbances of proteostasis. Defects of protein quality control occur in aging and have been linked to several disorders, including neurodegenerative diseases. However, the exact nature and time course of such disturbances in the context of brain diseases remain poorly understood. Sensors that allow visualization and quantitative analysis of proteostasis capacity in neurons are essential for gaining a better understanding of disease mechanisms and for testing potential therapies. Here, I provide an overview of available biosensors for assessing the functionality of the neuronal proteostasis network, point out the advantages and limitations of different sensors, and outline their potential for biological discoveries and translational applications. Frontiers Media S.A. 2022-03-08 /pmc/articles/PMC8957107/ /pubmed/35345600 http://dx.doi.org/10.3389/fnmol.2022.829365 Text en Copyright © 2022 Dudanova. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Dudanova, Irina
Biosensors for Studying Neuronal Proteostasis
title Biosensors for Studying Neuronal Proteostasis
title_full Biosensors for Studying Neuronal Proteostasis
title_fullStr Biosensors for Studying Neuronal Proteostasis
title_full_unstemmed Biosensors for Studying Neuronal Proteostasis
title_short Biosensors for Studying Neuronal Proteostasis
title_sort biosensors for studying neuronal proteostasis
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8957107/
https://www.ncbi.nlm.nih.gov/pubmed/35345600
http://dx.doi.org/10.3389/fnmol.2022.829365
work_keys_str_mv AT dudanovairina biosensorsforstudyingneuronalproteostasis