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Enhanced Medial Prefrontal Cortex and Hippocampal Activity Improves Memory Generalization in APP/PS1 Mice: A Multimodal Animal MRI Study

Memory generalization allows individuals to extend previously learned movement patterns to similar environments, contributing to cognitive flexibility. In Alzheimer’s disease (AD), the disturbance of generalization is responsible for the deficits of episodic memory, causing patients with AD to forge...

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Autores principales: Liu, Weilin, Li, Jianhong, Li, Le, Zhang, Yuhao, Yang, Minguang, Liang, Shengxiang, Li, Long, Dai, Yaling, Chen, Lewen, Jia, Weiwei, He, Xiaojun, Lin, Huawei, Tao, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977524/
https://www.ncbi.nlm.nih.gov/pubmed/35386301
http://dx.doi.org/10.3389/fncel.2022.848967
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author Liu, Weilin
Li, Jianhong
Li, Le
Zhang, Yuhao
Yang, Minguang
Liang, Shengxiang
Li, Long
Dai, Yaling
Chen, Lewen
Jia, Weiwei
He, Xiaojun
Lin, Huawei
Tao, Jing
author_facet Liu, Weilin
Li, Jianhong
Li, Le
Zhang, Yuhao
Yang, Minguang
Liang, Shengxiang
Li, Long
Dai, Yaling
Chen, Lewen
Jia, Weiwei
He, Xiaojun
Lin, Huawei
Tao, Jing
author_sort Liu, Weilin
collection PubMed
description Memory generalization allows individuals to extend previously learned movement patterns to similar environments, contributing to cognitive flexibility. In Alzheimer’s disease (AD), the disturbance of generalization is responsible for the deficits of episodic memory, causing patients with AD to forget or misplace things, even lose track of the way home. Cognitive training can effectively improve the cognition of patients with AD through changing thinking mode and memory flexibility. In this study, a T-shaped maze was utilized to simulate cognitive training in APP/PS1 mice to elucidate the potential mechanisms of beneficial effects after cognitive training. We found that cognitive training conducted by a T-shaped maze for 4 weeks can improve the memory generalization ability of APP/PS1 mice. The results of functional magnetic resonance imaging (fMRI) showed that the functional activity of the medial prefrontal cortex (mPFC) and hippocampus was enhanced after cognitive training, and the results of magnetic resonance spectroscopy (MRS) showed that the neurochemical metabolism of N-acetyl aspartate (NAA) and glutamic acid (Glu) in mPFC, hippocampus and reuniens (Re) thalamic nucleus were escalated. Furthermore, the functional activity of mPFC and hippocampus was negatively correlated with the escape latency in memory generalization test. Therefore, these results suggested that cognitive training might improve memory generalization through enhancing the functional activity of mPFC and hippocampus and increasing the metabolism of NAA and Glu in the brain regions of mPFC, hippocampus and Re nucleus.
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spelling pubmed-89775242022-04-05 Enhanced Medial Prefrontal Cortex and Hippocampal Activity Improves Memory Generalization in APP/PS1 Mice: A Multimodal Animal MRI Study Liu, Weilin Li, Jianhong Li, Le Zhang, Yuhao Yang, Minguang Liang, Shengxiang Li, Long Dai, Yaling Chen, Lewen Jia, Weiwei He, Xiaojun Lin, Huawei Tao, Jing Front Cell Neurosci Neuroscience Memory generalization allows individuals to extend previously learned movement patterns to similar environments, contributing to cognitive flexibility. In Alzheimer’s disease (AD), the disturbance of generalization is responsible for the deficits of episodic memory, causing patients with AD to forget or misplace things, even lose track of the way home. Cognitive training can effectively improve the cognition of patients with AD through changing thinking mode and memory flexibility. In this study, a T-shaped maze was utilized to simulate cognitive training in APP/PS1 mice to elucidate the potential mechanisms of beneficial effects after cognitive training. We found that cognitive training conducted by a T-shaped maze for 4 weeks can improve the memory generalization ability of APP/PS1 mice. The results of functional magnetic resonance imaging (fMRI) showed that the functional activity of the medial prefrontal cortex (mPFC) and hippocampus was enhanced after cognitive training, and the results of magnetic resonance spectroscopy (MRS) showed that the neurochemical metabolism of N-acetyl aspartate (NAA) and glutamic acid (Glu) in mPFC, hippocampus and reuniens (Re) thalamic nucleus were escalated. Furthermore, the functional activity of mPFC and hippocampus was negatively correlated with the escape latency in memory generalization test. Therefore, these results suggested that cognitive training might improve memory generalization through enhancing the functional activity of mPFC and hippocampus and increasing the metabolism of NAA and Glu in the brain regions of mPFC, hippocampus and Re nucleus. Frontiers Media S.A. 2022-03-21 /pmc/articles/PMC8977524/ /pubmed/35386301 http://dx.doi.org/10.3389/fncel.2022.848967 Text en Copyright © 2022 Liu, Li, Li, Zhang, Yang, Liang, Li, Dai, Chen, Jia, He, Lin and Tao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Liu, Weilin
Li, Jianhong
Li, Le
Zhang, Yuhao
Yang, Minguang
Liang, Shengxiang
Li, Long
Dai, Yaling
Chen, Lewen
Jia, Weiwei
He, Xiaojun
Lin, Huawei
Tao, Jing
Enhanced Medial Prefrontal Cortex and Hippocampal Activity Improves Memory Generalization in APP/PS1 Mice: A Multimodal Animal MRI Study
title Enhanced Medial Prefrontal Cortex and Hippocampal Activity Improves Memory Generalization in APP/PS1 Mice: A Multimodal Animal MRI Study
title_full Enhanced Medial Prefrontal Cortex and Hippocampal Activity Improves Memory Generalization in APP/PS1 Mice: A Multimodal Animal MRI Study
title_fullStr Enhanced Medial Prefrontal Cortex and Hippocampal Activity Improves Memory Generalization in APP/PS1 Mice: A Multimodal Animal MRI Study
title_full_unstemmed Enhanced Medial Prefrontal Cortex and Hippocampal Activity Improves Memory Generalization in APP/PS1 Mice: A Multimodal Animal MRI Study
title_short Enhanced Medial Prefrontal Cortex and Hippocampal Activity Improves Memory Generalization in APP/PS1 Mice: A Multimodal Animal MRI Study
title_sort enhanced medial prefrontal cortex and hippocampal activity improves memory generalization in app/ps1 mice: a multimodal animal mri study
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8977524/
https://www.ncbi.nlm.nih.gov/pubmed/35386301
http://dx.doi.org/10.3389/fncel.2022.848967
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