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Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis

Aging plays a critical role in the incidence and severity of infection, with age emerging as an independent predictor of mortality in sepsis. Trained immunity reprograms immunocytes to respond more rapidly and effectively to pathogens and serves as a potential approach to improve immune function in...

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Autores principales: Gill, P. Spencer, Ozment, Tammy R., Lewis, Nicole H., Sherwood, Edward R., Williams, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174537/
https://www.ncbi.nlm.nih.gov/pubmed/35693816
http://dx.doi.org/10.3389/fimmu.2022.872652
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author Gill, P. Spencer
Ozment, Tammy R.
Lewis, Nicole H.
Sherwood, Edward R.
Williams, David L.
author_facet Gill, P. Spencer
Ozment, Tammy R.
Lewis, Nicole H.
Sherwood, Edward R.
Williams, David L.
author_sort Gill, P. Spencer
collection PubMed
description Aging plays a critical role in the incidence and severity of infection, with age emerging as an independent predictor of mortality in sepsis. Trained immunity reprograms immunocytes to respond more rapidly and effectively to pathogens and serves as a potential approach to improve immune function in aging and/or sepsis. However, there is very little data on trained immunity in the aging immune system or in the presence of sepsis. We examined the impact of β-glucan induced innate immune training on monocytes from aging healthy humans (>60 years old) as well as sepsis patients. We observed increased metabolic capacity, upregulated cytokine secretion, increased H3K27 acetylation, and upregulation of crucial intracellular signaling pathways in trained monocytes from healthy aging subjects. The response to trained immunity in healthy aging monocytes was equivalent to the response of monocytes from younger, i.e., 18 – 59 years, individuals. Additionally, we found that trained immunity induced a unique expression pattern of cell surface markers in monocytes that was consistent across age groups. Trained monocytes from sepsis patients also displayed enhanced metabolic capacity and increased cytokine production. These results indicate that immune training can be induced in aging monocytes as well as monocytes from critically ill sepsis patients.
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spelling pubmed-91745372022-06-09 Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis Gill, P. Spencer Ozment, Tammy R. Lewis, Nicole H. Sherwood, Edward R. Williams, David L. Front Immunol Immunology Aging plays a critical role in the incidence and severity of infection, with age emerging as an independent predictor of mortality in sepsis. Trained immunity reprograms immunocytes to respond more rapidly and effectively to pathogens and serves as a potential approach to improve immune function in aging and/or sepsis. However, there is very little data on trained immunity in the aging immune system or in the presence of sepsis. We examined the impact of β-glucan induced innate immune training on monocytes from aging healthy humans (>60 years old) as well as sepsis patients. We observed increased metabolic capacity, upregulated cytokine secretion, increased H3K27 acetylation, and upregulation of crucial intracellular signaling pathways in trained monocytes from healthy aging subjects. The response to trained immunity in healthy aging monocytes was equivalent to the response of monocytes from younger, i.e., 18 – 59 years, individuals. Additionally, we found that trained immunity induced a unique expression pattern of cell surface markers in monocytes that was consistent across age groups. Trained monocytes from sepsis patients also displayed enhanced metabolic capacity and increased cytokine production. These results indicate that immune training can be induced in aging monocytes as well as monocytes from critically ill sepsis patients. Frontiers Media S.A. 2022-05-25 /pmc/articles/PMC9174537/ /pubmed/35693816 http://dx.doi.org/10.3389/fimmu.2022.872652 Text en Copyright © 2022 Gill, Ozment, Lewis, Sherwood and Williams https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Gill, P. Spencer
Ozment, Tammy R.
Lewis, Nicole H.
Sherwood, Edward R.
Williams, David L.
Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis
title Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis
title_full Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis
title_fullStr Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis
title_full_unstemmed Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis
title_short Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis
title_sort trained immunity enhances human monocyte function in aging and sepsis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9174537/
https://www.ncbi.nlm.nih.gov/pubmed/35693816
http://dx.doi.org/10.3389/fimmu.2022.872652
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