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From drug repositioning to target repositioning: prediction of therapeutic targets using genetically perturbed transcriptomic signatures
MOTIVATION: A critical element of drug development is the identification of therapeutic targets for diseases. However, the depletion of therapeutic targets is a serious problem. RESULTS: In this study, we propose the novel concept of target repositioning, an extension of the concept of drug repositi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235496/ https://www.ncbi.nlm.nih.gov/pubmed/35758779 http://dx.doi.org/10.1093/bioinformatics/btac240 |