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Extracellular 5′-methylthioadenosine inhibits intracellular symmetric dimethylarginine protein methylation of FUSE-binding proteins
Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine salvage pathway that converts the polyamine synthesis byproduct 5′-deoxy-5′-methylthioadenosine (MTA) into methionine. Inactivation of MTAP, often by homozygous deletion, is found in both solid and hematologic malignancies an...
Autores principales: | Tang, Baiqing, Lee, Hyung-Ok, Gupta, Sapna, Wang, Liqun, Kurimchak, Alison M., Duncan, James S., Kruger, Warren D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9467882/ https://www.ncbi.nlm.nih.gov/pubmed/35963436 http://dx.doi.org/10.1016/j.jbc.2022.102367 |
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