Synthesis and hybridizing properties of P-stereodefined chimeric [PS]-{DNA:RNA} and [PS]-{DNA:(2′-OMe)-RNA} oligomers

Oxathiaphospholane derivatives of 2′-OMe-ribonucleosides and 2′-O-TBDMS-ribonucleosides ((M)N-OTP and (T)N-OTP, respectively; nucleobase protected) were synthesized and separated into pure P-diastereomers. X-ray analysis showed the R(P) absolute configuration of the phosphorus atom in the fast-eluti...

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Detalles Bibliográficos
Autores principales: Jastrzębska, Katarzyna, Maciaszek, Anna, Dolot, Rafał, Tomaszewska-Antczak, Agnieszka, Mikołajczyk, Barbara, Guga, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491215/
https://www.ncbi.nlm.nih.gov/pubmed/36320848
http://dx.doi.org/10.1039/d2ra04855h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491215/
https://www.ncbi.nlm.nih.gov/pubmed/36320848
http://dx.doi.org/10.1039/d2ra04855h

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