Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure
Focused ultrasound (FUS) is a non-invasive neuromodulation technology that is being investigated for potential treatment of neurological and psychiatric disorders. Focused ultrasound combined with microbubbles can temporarily open the intact blood-brain barrier (BBB) of animals and humans, and facil...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949083/ https://www.ncbi.nlm.nih.gov/pubmed/36824864 http://dx.doi.org/10.1101/2023.02.16.528741 |
_version_ | 1784892905422323712 |
---|---|
author | Liu, D Munoz, F Sanatkhani, S Pouliopoulos, A N Konofagou, E Grinband, J VP, Ferrera |
author_facet | Liu, D Munoz, F Sanatkhani, S Pouliopoulos, A N Konofagou, E Grinband, J VP, Ferrera |
author_sort | Liu, D |
collection | PubMed |
description | Focused ultrasound (FUS) is a non-invasive neuromodulation technology that is being investigated for potential treatment of neurological and psychiatric disorders. Focused ultrasound combined with microbubbles can temporarily open the intact blood-brain barrier (BBB) of animals and humans, and facilitate drug delivery. FUS exposure, either with or without microbubbles, has been demonstrated to alter the behavior of non-human primates, and previous work has demonstrated transient and long-term effects of FUS neuromodulation on functional connectivity using resting state functional MRI. However, it is unknown whether opening the BBB affects functional connectivity differently than FUS alone. Thus we applied FUS alone (neuromodulation) and FUS with microbubbles (BBB opening) in the dorsal striatum of lightly anesthetized non-human primates, and compared changes in functional connectivity in major brain networks. We found different alteration patterns between FUS neuromodulation and FUS-mediated BBB opening in several cortical areas, and we also found that applying FUS to a deep brain structure can alter functional connectivity in the default mode network and frontotemporal network. |
format | Online Article Text |
id | pubmed-9949083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-99490832023-02-24 Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure Liu, D Munoz, F Sanatkhani, S Pouliopoulos, A N Konofagou, E Grinband, J VP, Ferrera bioRxiv Article Focused ultrasound (FUS) is a non-invasive neuromodulation technology that is being investigated for potential treatment of neurological and psychiatric disorders. Focused ultrasound combined with microbubbles can temporarily open the intact blood-brain barrier (BBB) of animals and humans, and facilitate drug delivery. FUS exposure, either with or without microbubbles, has been demonstrated to alter the behavior of non-human primates, and previous work has demonstrated transient and long-term effects of FUS neuromodulation on functional connectivity using resting state functional MRI. However, it is unknown whether opening the BBB affects functional connectivity differently than FUS alone. Thus we applied FUS alone (neuromodulation) and FUS with microbubbles (BBB opening) in the dorsal striatum of lightly anesthetized non-human primates, and compared changes in functional connectivity in major brain networks. We found different alteration patterns between FUS neuromodulation and FUS-mediated BBB opening in several cortical areas, and we also found that applying FUS to a deep brain structure can alter functional connectivity in the default mode network and frontotemporal network. Cold Spring Harbor Laboratory 2023-02-16 /pmc/articles/PMC9949083/ /pubmed/36824864 http://dx.doi.org/10.1101/2023.02.16.528741 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Liu, D Munoz, F Sanatkhani, S Pouliopoulos, A N Konofagou, E Grinband, J VP, Ferrera Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure |
title | Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure |
title_full | Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure |
title_fullStr | Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure |
title_full_unstemmed | Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure |
title_short | Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure |
title_sort | alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949083/ https://www.ncbi.nlm.nih.gov/pubmed/36824864 http://dx.doi.org/10.1101/2023.02.16.528741 |
work_keys_str_mv | AT liud alterationoffunctionalconnectivityinthecortexandmajorbrainnetworksofnonhumanprimatesfollowingfocusedultrasoundexposure AT munozf alterationoffunctionalconnectivityinthecortexandmajorbrainnetworksofnonhumanprimatesfollowingfocusedultrasoundexposure AT sanatkhanis alterationoffunctionalconnectivityinthecortexandmajorbrainnetworksofnonhumanprimatesfollowingfocusedultrasoundexposure AT pouliopoulosan alterationoffunctionalconnectivityinthecortexandmajorbrainnetworksofnonhumanprimatesfollowingfocusedultrasoundexposure AT konofagoue alterationoffunctionalconnectivityinthecortexandmajorbrainnetworksofnonhumanprimatesfollowingfocusedultrasoundexposure AT grinbandj alterationoffunctionalconnectivityinthecortexandmajorbrainnetworksofnonhumanprimatesfollowingfocusedultrasoundexposure AT vpferrera alterationoffunctionalconnectivityinthecortexandmajorbrainnetworksofnonhumanprimatesfollowingfocusedultrasoundexposure |