Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure

Focused ultrasound (FUS) is a non-invasive neuromodulation technology that is being investigated for potential treatment of neurological and psychiatric disorders. Focused ultrasound combined with microbubbles can temporarily open the intact blood-brain barrier (BBB) of animals and humans, and facil...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, D, Munoz, F, Sanatkhani, S, Pouliopoulos, A N, Konofagou, E, Grinband, J, VP, Ferrera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949083/
https://www.ncbi.nlm.nih.gov/pubmed/36824864
http://dx.doi.org/10.1101/2023.02.16.528741
_version_ 1784892905422323712
author Liu, D
Munoz, F
Sanatkhani, S
Pouliopoulos, A N
Konofagou, E
Grinband, J
VP, Ferrera
author_facet Liu, D
Munoz, F
Sanatkhani, S
Pouliopoulos, A N
Konofagou, E
Grinband, J
VP, Ferrera
author_sort Liu, D
collection PubMed
description Focused ultrasound (FUS) is a non-invasive neuromodulation technology that is being investigated for potential treatment of neurological and psychiatric disorders. Focused ultrasound combined with microbubbles can temporarily open the intact blood-brain barrier (BBB) of animals and humans, and facilitate drug delivery. FUS exposure, either with or without microbubbles, has been demonstrated to alter the behavior of non-human primates, and previous work has demonstrated transient and long-term effects of FUS neuromodulation on functional connectivity using resting state functional MRI. However, it is unknown whether opening the BBB affects functional connectivity differently than FUS alone. Thus we applied FUS alone (neuromodulation) and FUS with microbubbles (BBB opening) in the dorsal striatum of lightly anesthetized non-human primates, and compared changes in functional connectivity in major brain networks. We found different alteration patterns between FUS neuromodulation and FUS-mediated BBB opening in several cortical areas, and we also found that applying FUS to a deep brain structure can alter functional connectivity in the default mode network and frontotemporal network.
format Online
Article
Text
id pubmed-9949083
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Cold Spring Harbor Laboratory
record_format MEDLINE/PubMed
spelling pubmed-99490832023-02-24 Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure Liu, D Munoz, F Sanatkhani, S Pouliopoulos, A N Konofagou, E Grinband, J VP, Ferrera bioRxiv Article Focused ultrasound (FUS) is a non-invasive neuromodulation technology that is being investigated for potential treatment of neurological and psychiatric disorders. Focused ultrasound combined with microbubbles can temporarily open the intact blood-brain barrier (BBB) of animals and humans, and facilitate drug delivery. FUS exposure, either with or without microbubbles, has been demonstrated to alter the behavior of non-human primates, and previous work has demonstrated transient and long-term effects of FUS neuromodulation on functional connectivity using resting state functional MRI. However, it is unknown whether opening the BBB affects functional connectivity differently than FUS alone. Thus we applied FUS alone (neuromodulation) and FUS with microbubbles (BBB opening) in the dorsal striatum of lightly anesthetized non-human primates, and compared changes in functional connectivity in major brain networks. We found different alteration patterns between FUS neuromodulation and FUS-mediated BBB opening in several cortical areas, and we also found that applying FUS to a deep brain structure can alter functional connectivity in the default mode network and frontotemporal network. Cold Spring Harbor Laboratory 2023-02-16 /pmc/articles/PMC9949083/ /pubmed/36824864 http://dx.doi.org/10.1101/2023.02.16.528741 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Liu, D
Munoz, F
Sanatkhani, S
Pouliopoulos, A N
Konofagou, E
Grinband, J
VP, Ferrera
Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure
title Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure
title_full Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure
title_fullStr Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure
title_full_unstemmed Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure
title_short Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure
title_sort alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949083/
https://www.ncbi.nlm.nih.gov/pubmed/36824864
http://dx.doi.org/10.1101/2023.02.16.528741
work_keys_str_mv AT liud alterationoffunctionalconnectivityinthecortexandmajorbrainnetworksofnonhumanprimatesfollowingfocusedultrasoundexposure
AT munozf alterationoffunctionalconnectivityinthecortexandmajorbrainnetworksofnonhumanprimatesfollowingfocusedultrasoundexposure
AT sanatkhanis alterationoffunctionalconnectivityinthecortexandmajorbrainnetworksofnonhumanprimatesfollowingfocusedultrasoundexposure
AT pouliopoulosan alterationoffunctionalconnectivityinthecortexandmajorbrainnetworksofnonhumanprimatesfollowingfocusedultrasoundexposure
AT konofagoue alterationoffunctionalconnectivityinthecortexandmajorbrainnetworksofnonhumanprimatesfollowingfocusedultrasoundexposure
AT grinbandj alterationoffunctionalconnectivityinthecortexandmajorbrainnetworksofnonhumanprimatesfollowingfocusedultrasoundexposure
AT vpferrera alterationoffunctionalconnectivityinthecortexandmajorbrainnetworksofnonhumanprimatesfollowingfocusedultrasoundexposure