Cargando…

A1 TARGETING IL-4 AND IL-13 TO TREAT CROHN’S DISEASE-ASSOCIATED INTESTINAL FIBROSIS IN SHIP DEFICIENT MICE

BACKGROUND: Crohn’s disease (CD) is an immune-mediated disease characterized by chronic, relapsing and remitting, or progressive inflammation of the digestive tract. One in 3 people with CD will develop intestinal fibrosis requiring surgery within 10 years of diagnosis. Biological therapy is effecti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Safari, K, Menzies, S, Jung, H, Sly, L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Oral Presentations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9991372/ http://dx.doi.org/10.1093/jcag/gwac036.001

Ejemplares similares

IL-15 deficient Tax mice reveal a role for IL-1α in tumor immunity
por: Rauch, Daniel A, et al.
Publicado: (2014)

Sputum interleukin (IL)-13 as a biomarker for the evaluation of asthma control
por: Tsilogianni, Zoi, et al.
Publicado: (2015)

Sputum “IL-5, IL-17A, IL-25-high” pattern is associated with uncontrolled asthma and worse lung function
por: Seys, Sven, et al.
Publicado: (2013)

Compositional changes to the ileal microbiome precede the onset of spontaneous ileitis in SHIP deficient mice
por: Dobranowski, Peter Allan, et al.
Publicado: (2019)

Effect of the combination of the proinflammatory cytokines IL-1, tumor necrosis factor-α and IL-17
por: Miossec, P, et al.
Publicado: (2003)

Cytokine production by dendritic cells genetically engineered to express IL-4: induction of Th2 responses and differential regulation of IL-12 and IL-23 synthesis
por: Fox, D, et al.
Publicado: (2003)

Role of IL-1b in NLRP12-associated autoinflammatory disorders and resistance to anti-IL-1 therapy
por: Jeru, Isabelle, et al.
Publicado: (2011)

IL-17, synoviolin and rheumatoid arthritis chronicity
por: Miossec, Pierre
Publicado: (2012)

Natural Treg and role of IL-2 in lupus
por: Riemekasten, Gabriela, et al.
Publicado: (2011)

MicroRNA-mediated regulation of IL-10, IL-12 and TNFα gene expression in severely injured trauma patients
por: Jones, Timothy F, et al.
Publicado: (2015)

Candidate targets for antibody therapy of rheumatoid arthritis: CD64 and IL-15
por: van de Winkel, J
Publicado: (2003)

12.2 Mevalonate kinase deficiency: Impaired isoprenoid synthesis induces IL-1beta production via activation of Rac1
por: Kuijk, LM, et al.
Publicado: (2008)

Host genetics of HCV disease — IL28B
por: Fellay, J
Publicado: (2010)

The role of IL-17 in the development of arthritis in mouse models
por: Iwakura, Y, et al.
Publicado: (2003)

PReS-FINAL-2181: Recombinant il-1ra restores the il-18-nk cell axis in steroid naive systemic juvenile idiopathic arthritis
por: De Jager, W, et al.
Publicado: (2013)

Implication of IL-18 in chronic inflammation of severe refractory asthma
por: Rovina, Nikoletta, et al.
Publicado: (2015)

Regulation of angiogenesis by angiostatin through immune cells and IL 12 production
por: Noonan, Douglas M, et al.
Publicado: (2006)

9. Successful use of IL-6 pathway blockade to treat autoinflammation occurring in the context of a novel TNFRS1A gene mutation
por: Dyke, Bernard, et al.
Publicado: (2019)

PD-1, IL-10, IFN-γ and IL-12 form a network to regulate HIV-1-specific CD4 T Cell and antigen-presenting cell function
por: Porichis, F, et al.
Publicado: (2012)

Regulated intratumoral expression of IL-12 as a basis for combination therapy in melanoma
por: Nemunaitis, John J, et al.
Publicado: (2014)

The roles of basophils, TSLP and IL-33 in food allergy following epicutaneous sensitisation
por: Yoshimoto, Tomohiro, et al.
Publicado: (2015)

S9.5c Malassezia-host interactions and the Il-23/17 axis
por: LeibundGut-Landmann, Salomé
Publicado: (2022)

OA21 Are novel anti-IL5 biologics triggering rheumatoid arthritis?
por: Dean, Nathan, et al.
Publicado: (2023)

Regulation of HIV-1 and IL-2 transcription by inducible CAMP early repressor (ICER)
por: Bodor, Josef
Publicado: (2006)

TIMP-3 inhibits aggrecan breakdown in pig articular cartilage stimulated with IL-1
por: Nagase, H, et al.
Publicado: (2003)

Altered expression of IL-10 family cytokines in CRMO result in enhanced inflammasome activation
por: Hofmann, S, et al.
Publicado: (2015)

8. An autoinflammatory syndrome resembling Castleman’s disease with excellent response to IL-6 blockade
por: Chakravorty, Mithun, et al.
Publicado: (2019)

IL-10 Treatment Is Associated with Prohibitin Expression in the Crohn's Disease Intestinal Fibrosis Mouse Model
por: Yuan, C., et al.
Publicado: (2013)

Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia
por: Zhang, Meili, et al.
Publicado: (2015)

SHIP deficiency causes Crohn's disease-like ileitis
por: Kerr, William G, et al.
Publicado: (2010)

The Role of IL-13 and IL-4 in Adipose Tissue Fibrosis
por: Arndt, Lilli, et al.
Publicado: (2023)

Recombinant IL1-RA in the early phase of systemic onset JIA: before the onset of arthritis
por: Vastert, SJ, et al.
Publicado: (2011)

A decade of anti-IL-1 therapy in CAPS - a spectrum of efficacy in this spectrum of diseases
por: Lane, T, et al.
Publicado: (2015)

A3 CROHN’S DISEASE PROTEOLYTIC MICROBIOTA ENHANCES INFLAMMATION THROUGH PAR2 PATHWAY IN GNOTOBIOTIC MICE
por: Hann, A, et al.
Publicado: (2023)

Leukemia/lymphoma development in IL-15-deficient TCR-transgenic mice
por: Dubois, Sigrid, et al.
Publicado: (2015)

IL-21R mRNA is overexpressed in systemic sclerosis and contributes to the epidermal/dermal cross-talk
por: Distler, O, et al.
Publicado: (2003)

Anti-TNF antibody therapy induces IL-17 suppressing regulatory T cells in patients with rheumatoid arthritis
por: McGovern, Jenny, et al.
Publicado: (2012)

Linking genotype to cell function in chronic inflammation: analysis of the IL-23/Th17 axis in spondylarthropathy
por: Roumier, M, et al.
Publicado: (2010)

TNF dependency of IL-17-induced joint pathology can be circumvented by Toll-like receptor-2 signaling
por: Van den Berg, W, et al.
Publicado: (2003)

Regulation of inflammatory immune responses leading to the development of bone destructive autoimmune disease rheumatoid arthritis by IL-27
por: Yoshimoto, Takayuki, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_qntrh2loh1kpkjakm5mhp7k9p8