Molecular basis of stepwise cyclic tetra-adenylate cleavage by the type III CRISPR ring nuclease Crn1/Sso2081

The cyclic oligoadenylates (cOAs) act as second messengers of the type III CRISPR immunity system through activating the auxiliary nucleases for indiscriminate RNA degradation. The cOA-degrading nucleases (ring nucleases) provide an ‘off-switch’ regulation of the signaling, thereby preventing cell d...

Descripción completa

Detalles Bibliográficos
Autores principales: Du, Liyang, Zhang, Danping, Luo, Zhipu, Lin, Zhonghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018336/
https://www.ncbi.nlm.nih.gov/pubmed/36807980
http://dx.doi.org/10.1093/nar/gkad101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018336/
https://www.ncbi.nlm.nih.gov/pubmed/36807980
http://dx.doi.org/10.1093/nar/gkad101

Ejemplares similares