New K50R mutant mouse models reveal impaired hypusination of eif5a2 with alterations in cell metabolite landscape

The eukaryotic translation initiation factor 5A1 (eIF5A1) and 5A2 (eIF5A2) are important proteins in a variety of physiological and pathophysiological processes and their function has been linked to neurodevelopmental disorders, cancer, and viral infections. Here, we report two new genome-edited mou...

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Detalles Bibliográficos
Autores principales: Schultz, Chad R., Sheldon, Ryan D., Xie, Huirong, Demireva, Elena Y., Uhl, Katie L., Agnew, Dalen W., Geerts, Dirk, Bachmann, André S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084858/
https://www.ncbi.nlm.nih.gov/pubmed/36848144
http://dx.doi.org/10.1242/bio.059647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10084858/
https://www.ncbi.nlm.nih.gov/pubmed/36848144
http://dx.doi.org/10.1242/bio.059647

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