Resistin targets TAZ to promote osteogenic differentiation through PI3K/AKT/mTOR pathway

Osteogenic differentiation (OD) of bone marrow mesenchymal stem cells (BMSCs) contributes significantly to the regeneration of bone defects. Resistin, an adipose tissue-specific secretory factor, has been shown to involve many different functions, including metabolism, inflammation, cancer, and bone...

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Autores principales: Shang, JingJing, Yu, Zhentang, Xiong, Chengwei, Zhang, Junjie, Gong, Jinhong, Yu, Changlin, Huang, Yong, Zhou, Xindie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300212/
https://www.ncbi.nlm.nih.gov/pubmed/37389179
http://dx.doi.org/10.1016/j.isci.2023.107025
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author Shang, JingJing
Yu, Zhentang
Xiong, Chengwei
Zhang, Junjie
Gong, Jinhong
Yu, Changlin
Huang, Yong
Zhou, Xindie
author_facet Shang, JingJing
Yu, Zhentang
Xiong, Chengwei
Zhang, Junjie
Gong, Jinhong
Yu, Changlin
Huang, Yong
Zhou, Xindie
author_sort Shang, JingJing
collection PubMed
description Osteogenic differentiation (OD) of bone marrow mesenchymal stem cells (BMSCs) contributes significantly to the regeneration of bone defects. Resistin, an adipose tissue-specific secretory factor, has been shown to involve many different functions, including metabolism, inflammation, cancer, and bone remodeling. However, the effects and mechanisms of resistin on OD of BMSCs remain unclear. Herein, we demonstrated that resistin was highly expressed in BMSCs with OD. Upregulation of resistin contributed to the progression of OD of BMSCs by activating PI3K/AKT/mTOR signaling pathway. In addition, resistin facilitated OD by targeting transcriptional co-activator with PDZ-binding motif (TAZ). In a rat femoral condyle bone defect model, local injection of resistin significantly promoted bone repair and improved bone formation. This work contributes to better understanding the mechanism of resistin directly involved in the OD and might provide a new therapeutic strategy for bone defect regeneration.
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spelling pubmed-103002122023-06-29 Resistin targets TAZ to promote osteogenic differentiation through PI3K/AKT/mTOR pathway Shang, JingJing Yu, Zhentang Xiong, Chengwei Zhang, Junjie Gong, Jinhong Yu, Changlin Huang, Yong Zhou, Xindie iScience Article Osteogenic differentiation (OD) of bone marrow mesenchymal stem cells (BMSCs) contributes significantly to the regeneration of bone defects. Resistin, an adipose tissue-specific secretory factor, has been shown to involve many different functions, including metabolism, inflammation, cancer, and bone remodeling. However, the effects and mechanisms of resistin on OD of BMSCs remain unclear. Herein, we demonstrated that resistin was highly expressed in BMSCs with OD. Upregulation of resistin contributed to the progression of OD of BMSCs by activating PI3K/AKT/mTOR signaling pathway. In addition, resistin facilitated OD by targeting transcriptional co-activator with PDZ-binding motif (TAZ). In a rat femoral condyle bone defect model, local injection of resistin significantly promoted bone repair and improved bone formation. This work contributes to better understanding the mechanism of resistin directly involved in the OD and might provide a new therapeutic strategy for bone defect regeneration. Elsevier 2023-06-07 /pmc/articles/PMC10300212/ /pubmed/37389179 http://dx.doi.org/10.1016/j.isci.2023.107025 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Shang, JingJing
Yu, Zhentang
Xiong, Chengwei
Zhang, Junjie
Gong, Jinhong
Yu, Changlin
Huang, Yong
Zhou, Xindie
Resistin targets TAZ to promote osteogenic differentiation through PI3K/AKT/mTOR pathway
title Resistin targets TAZ to promote osteogenic differentiation through PI3K/AKT/mTOR pathway
title_full Resistin targets TAZ to promote osteogenic differentiation through PI3K/AKT/mTOR pathway
title_fullStr Resistin targets TAZ to promote osteogenic differentiation through PI3K/AKT/mTOR pathway
title_full_unstemmed Resistin targets TAZ to promote osteogenic differentiation through PI3K/AKT/mTOR pathway
title_short Resistin targets TAZ to promote osteogenic differentiation through PI3K/AKT/mTOR pathway
title_sort resistin targets taz to promote osteogenic differentiation through pi3k/akt/mtor pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300212/
https://www.ncbi.nlm.nih.gov/pubmed/37389179
http://dx.doi.org/10.1016/j.isci.2023.107025
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