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Imiquimod-induced pruritus in female wild-type and knockin Wistar rats: underscoring behavioral scratching in a rat model for antipruritic treatments

OBJECTIVES: Animal models of skin disease are used to evaluate therapeutics to alleviate disease. One common clinical dermatological complaint is pruritus (itch), but there is a lack of standardization in the characterization of pre-clinical models and scratching behavior, a key itch endpoint, is of...

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Detalles Bibliográficos
Autores principales: Lariosa-Willingham, Karen, Leonoudakis, Dmitri, Simon, Florian, Walker, Kendall, Guillaume, Philippe, Warren, Liling, Stratton, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10675923/
https://www.ncbi.nlm.nih.gov/pubmed/38007440
http://dx.doi.org/10.1186/s13104-023-06627-1