Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1)

Overexpression of cyclin E, an activator of cyclin-dependent kinase 2, has been linked to human cancer. In cell culture models, the forced expression of cyclin E leads to aneuploidy and polyploidy, which is consistent with a direct role of cyclin E overexpression in tumorigenesis. In this study, we...

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Detalles Bibliográficos
Autores principales: Keck, Jamie M., Summers, Matthew K., Tedesco, Donato, Ekholm-Reed, Susanna, Chuang, Li-Chiou, Jackson, Peter K., Reed, Steven I.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2007
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064850/
https://www.ncbi.nlm.nih.gov/pubmed/17664332
http://dx.doi.org/10.1083/jcb.200703202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064850/
https://www.ncbi.nlm.nih.gov/pubmed/17664332
http://dx.doi.org/10.1083/jcb.200703202

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