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Thiazole Antibiotics Target FoxM1 and Induce Apoptosis in Human Cancer Cells

Forkhead box M1 (FoxM1) oncogenic transcription factor represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors. Recently, using a cell-based assay system we identified thiazole antibiotic Siomycin A as an inhibitor of FoxM1 t...

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Detalles Bibliográficos
Autores principales: Bhat, Uppoor G., Halasi, Marianna, Gartel, Andrei L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680058/
https://www.ncbi.nlm.nih.gov/pubmed/19440351
http://dx.doi.org/10.1371/journal.pone.0005592