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Short Telomeres in ESCs Lead to Unstable Differentiation

Functional telomeres are critical for stem cell proliferation; however, whether they are equally important for the stability of stem cell differentiation is not known. We found that mouse embryonic stem cells (ESCs) with critically short telomeres (Tert(−/−) ESCs) initiated normal differentiation af...

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Detalles Bibliográficos
Autores principales: Pucci, Fabio, Gardano, Laura, Harrington, Lea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629568/
https://www.ncbi.nlm.nih.gov/pubmed/23561444
http://dx.doi.org/10.1016/j.stem.2013.01.018