EndoS Reduces the Pathogenicity of Anti-mCOL7 IgG through Reduced Binding of Immune Complexes to Neutrophils
Endo-β-N-acetylglucosaminidase (EndoS) has been shown to act as a potent pathogen-derived immunomodulatory molecule in autoimmune diseases. Here we investigated how EndoS treatment reduces the pathogenicity of rabbit anti-mCOL7 IgG using different experimental models of epidermolysis bullosa acquisi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913582/ https://www.ncbi.nlm.nih.gov/pubmed/24504190 http://dx.doi.org/10.1371/journal.pone.0085317 |
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author | Yu, Xinhua Zheng, Junfeng Collin, Mattias Schmidt, Enno Zillikens, Detlef Petersen, Frank |
author_facet | Yu, Xinhua Zheng, Junfeng Collin, Mattias Schmidt, Enno Zillikens, Detlef Petersen, Frank |
author_sort | Yu, Xinhua |
collection | PubMed |
description | Endo-β-N-acetylglucosaminidase (EndoS) has been shown to act as a potent pathogen-derived immunomodulatory molecule in autoimmune diseases. Here we investigated how EndoS treatment reduces the pathogenicity of rabbit anti-mCOL7 IgG using different experimental models of epidermolysis bullosa acquisita (EBA). Our results show that the EndoS treatment does not interfere with the binding of the antibody to the antigen but reduces immune complex (IC)-mediated neutrophil activation by impairing the binding of the IC to FcγR on neutrophils. On the basis of this newly identified EndoS-mediated mechanism we hope to develop new strategies in the treatment of the disease. |
format | Online Article Text |
id | pubmed-3913582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39135822014-02-06 EndoS Reduces the Pathogenicity of Anti-mCOL7 IgG through Reduced Binding of Immune Complexes to Neutrophils Yu, Xinhua Zheng, Junfeng Collin, Mattias Schmidt, Enno Zillikens, Detlef Petersen, Frank PLoS One Research Article Endo-β-N-acetylglucosaminidase (EndoS) has been shown to act as a potent pathogen-derived immunomodulatory molecule in autoimmune diseases. Here we investigated how EndoS treatment reduces the pathogenicity of rabbit anti-mCOL7 IgG using different experimental models of epidermolysis bullosa acquisita (EBA). Our results show that the EndoS treatment does not interfere with the binding of the antibody to the antigen but reduces immune complex (IC)-mediated neutrophil activation by impairing the binding of the IC to FcγR on neutrophils. On the basis of this newly identified EndoS-mediated mechanism we hope to develop new strategies in the treatment of the disease. Public Library of Science 2014-02-04 /pmc/articles/PMC3913582/ /pubmed/24504190 http://dx.doi.org/10.1371/journal.pone.0085317 Text en © 2014 Yu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Yu, Xinhua Zheng, Junfeng Collin, Mattias Schmidt, Enno Zillikens, Detlef Petersen, Frank EndoS Reduces the Pathogenicity of Anti-mCOL7 IgG through Reduced Binding of Immune Complexes to Neutrophils |
title | EndoS Reduces the Pathogenicity of Anti-mCOL7 IgG through Reduced Binding of Immune Complexes to Neutrophils |
title_full | EndoS Reduces the Pathogenicity of Anti-mCOL7 IgG through Reduced Binding of Immune Complexes to Neutrophils |
title_fullStr | EndoS Reduces the Pathogenicity of Anti-mCOL7 IgG through Reduced Binding of Immune Complexes to Neutrophils |
title_full_unstemmed | EndoS Reduces the Pathogenicity of Anti-mCOL7 IgG through Reduced Binding of Immune Complexes to Neutrophils |
title_short | EndoS Reduces the Pathogenicity of Anti-mCOL7 IgG through Reduced Binding of Immune Complexes to Neutrophils |
title_sort | endos reduces the pathogenicity of anti-mcol7 igg through reduced binding of immune complexes to neutrophils |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913582/ https://www.ncbi.nlm.nih.gov/pubmed/24504190 http://dx.doi.org/10.1371/journal.pone.0085317 |
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