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Defects in TLR3 expression and RNase L activation lead to decreased MnSOD expression and insulin resistance in muscle cells of obese people
Obesity is associated with chronic low-grade inflammation and oxidative stress that blunt insulin response in its target tissues, leading to insulin resistance (IR). IR is a characteristic feature of type 2 diabetes. Skeletal muscle is responsible for 75% of total insulin-dependent glucose uptake; c...
Autores principales: | Fabre, O, Breuker, C, Amouzou, C, Salehzada, T, Kitzmann, M, Mercier, J, Bisbal, C |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973244/ https://www.ncbi.nlm.nih.gov/pubmed/24651439 http://dx.doi.org/10.1038/cddis.2014.104 |
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