Length-dependent gene misexpression is associated with Alzheimer’s disease progression

Recent reports show transcription preference for long genes in neuronal tissues compared with non-neuronal tissues, and a gene-length dependent change in expression in the neurodevelopmental disease Rett syndrome (RTT). Whether the gene-length dependent changes in expression seen in RTT might also b...

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Autores principales: Barbash, Shahar, Sakmar, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428066/
https://www.ncbi.nlm.nih.gov/pubmed/28298623
http://dx.doi.org/10.1038/s41598-017-00250-4
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author Barbash, Shahar
Sakmar, Thomas P.
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Sakmar, Thomas P.
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description Recent reports show transcription preference for long genes in neuronal tissues compared with non-neuronal tissues, and a gene-length dependent change in expression in the neurodevelopmental disease Rett syndrome (RTT). Whether the gene-length dependent changes in expression seen in RTT might also be seen in neurodegenerative diseases is not yet known. However, a reasonable hypothesis is that similar effects might be seen in neurodegenerative diseases as well as in RTT since a common general feature of both illnesses involves progressive dysfunction of synapses. Here, we demonstrate a clear length-dependent gene misexpression in the most prevalent neurodegenerative disease, Alzheimer’s disease. We show that the effect is associated with disease progression and can be attributed specifically to neurons. In particular, we observed gene length-dependent down regulation on the level of the whole tissue and gene length-dependent up regulation on the level of single cells. Our analysis shows that a gene-length effect on expression can be found in degenerative neurological illnesses, such as Alzheimer’s disease. Additional investigation to elucidate the precise mechanism underlying gene-length dependent changes in expression is warranted.
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spelling pubmed-54280662017-05-15 Length-dependent gene misexpression is associated with Alzheimer’s disease progression Barbash, Shahar Sakmar, Thomas P. Sci Rep Article Recent reports show transcription preference for long genes in neuronal tissues compared with non-neuronal tissues, and a gene-length dependent change in expression in the neurodevelopmental disease Rett syndrome (RTT). Whether the gene-length dependent changes in expression seen in RTT might also be seen in neurodegenerative diseases is not yet known. However, a reasonable hypothesis is that similar effects might be seen in neurodegenerative diseases as well as in RTT since a common general feature of both illnesses involves progressive dysfunction of synapses. Here, we demonstrate a clear length-dependent gene misexpression in the most prevalent neurodegenerative disease, Alzheimer’s disease. We show that the effect is associated with disease progression and can be attributed specifically to neurons. In particular, we observed gene length-dependent down regulation on the level of the whole tissue and gene length-dependent up regulation on the level of single cells. Our analysis shows that a gene-length effect on expression can be found in degenerative neurological illnesses, such as Alzheimer’s disease. Additional investigation to elucidate the precise mechanism underlying gene-length dependent changes in expression is warranted. Nature Publishing Group UK 2017-03-15 /pmc/articles/PMC5428066/ /pubmed/28298623 http://dx.doi.org/10.1038/s41598-017-00250-4 Text en © The Author(s) 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Barbash, Shahar
Sakmar, Thomas P.
Length-dependent gene misexpression is associated with Alzheimer’s disease progression
title Length-dependent gene misexpression is associated with Alzheimer’s disease progression
title_full Length-dependent gene misexpression is associated with Alzheimer’s disease progression
title_fullStr Length-dependent gene misexpression is associated with Alzheimer’s disease progression
title_full_unstemmed Length-dependent gene misexpression is associated with Alzheimer’s disease progression
title_short Length-dependent gene misexpression is associated with Alzheimer’s disease progression
title_sort length-dependent gene misexpression is associated with alzheimer’s disease progression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428066/
https://www.ncbi.nlm.nih.gov/pubmed/28298623
http://dx.doi.org/10.1038/s41598-017-00250-4
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