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CdpR Inhibits CRISPR-Cas Adaptive Immunity to Lower Anti-viral Defense while Avoiding Self-Reactivity

CRISPR-Cas systems as adaptive immunity in bacteria and archaea battle against bacteriophages. However, little is known how CRISPR-Cas systems are precisely regulated to effectively eliminate intruders while not inducing self-reactivity. Here, we identify intrinsic negative modulator of CRISPR-Cas t...

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Detalles Bibliográficos
Autores principales:	Lin, Ping, Pu, Qinqin, Shen, Guanwang, Li, Rongpeng, Guo, Kai, Zhou, Chuanmin, Liang, Haihua, Jiang, Jianxin, Wu, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393702/ https://www.ncbi.nlm.nih.gov/pubmed/30822746 http://dx.doi.org/10.1016/j.isci.2019.02.005

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