Dram1 regulates DNA damage-induced alternative autophagy
Autophagy is an evolutionarily conserved process that degrades subcellular constituents. Mammalian cells undergo two types of autophagy; Atg5-dependent conventional autophagy and Atg5-independent alternative autophagy, and the molecules required for the latter type of autophagy are largely unknown....
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shared Science Publishers OG
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558930/ https://www.ncbi.nlm.nih.gov/pubmed/31225467 http://dx.doi.org/10.15698/cst2018.03.127 |
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author | Nagata, Meruna Arakawa, Satoko Yamaguchi, Hirofumi Torii, Satoru Endo, Hazuki Tsujioka, Masatsune Honda, Shinya Nishida, Yuya Konishi, Akimitsu Shimizu, Shigeomi |
author_facet | Nagata, Meruna Arakawa, Satoko Yamaguchi, Hirofumi Torii, Satoru Endo, Hazuki Tsujioka, Masatsune Honda, Shinya Nishida, Yuya Konishi, Akimitsu Shimizu, Shigeomi |
author_sort | Nagata, Meruna |
collection | PubMed |
description | Autophagy is an evolutionarily conserved process that degrades subcellular constituents. Mammalian cells undergo two types of autophagy; Atg5-dependent conventional autophagy and Atg5-independent alternative autophagy, and the molecules required for the latter type of autophagy are largely unknown. In this study, we analyzed the molecular mechanisms of genotoxic stress-induced alternative autophagy, and identified the essential role of p53 and damage-regulated autophagy modulator (Dram1). Dram1 was sufficient to induce alternative autophagy. In the mechanism of alternative autophagy, Dram1 functions in the closure of isolation membranes downstream of p53. These findings indicate that Dram1 plays a pivotal role in genotoxic stress-induced alternative autophagy. |
format | Online Article Text |
id | pubmed-6558930 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Shared Science Publishers OG |
record_format | MEDLINE/PubMed |
spelling | pubmed-65589302019-06-20 Dram1 regulates DNA damage-induced alternative autophagy Nagata, Meruna Arakawa, Satoko Yamaguchi, Hirofumi Torii, Satoru Endo, Hazuki Tsujioka, Masatsune Honda, Shinya Nishida, Yuya Konishi, Akimitsu Shimizu, Shigeomi Cell Stress Research Article Autophagy is an evolutionarily conserved process that degrades subcellular constituents. Mammalian cells undergo two types of autophagy; Atg5-dependent conventional autophagy and Atg5-independent alternative autophagy, and the molecules required for the latter type of autophagy are largely unknown. In this study, we analyzed the molecular mechanisms of genotoxic stress-induced alternative autophagy, and identified the essential role of p53 and damage-regulated autophagy modulator (Dram1). Dram1 was sufficient to induce alternative autophagy. In the mechanism of alternative autophagy, Dram1 functions in the closure of isolation membranes downstream of p53. These findings indicate that Dram1 plays a pivotal role in genotoxic stress-induced alternative autophagy. Shared Science Publishers OG 2018-03-07 /pmc/articles/PMC6558930/ /pubmed/31225467 http://dx.doi.org/10.15698/cst2018.03.127 Text en Copyright: © 2018 Nagata et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged. |
spellingShingle | Research Article Nagata, Meruna Arakawa, Satoko Yamaguchi, Hirofumi Torii, Satoru Endo, Hazuki Tsujioka, Masatsune Honda, Shinya Nishida, Yuya Konishi, Akimitsu Shimizu, Shigeomi Dram1 regulates DNA damage-induced alternative autophagy |
title | Dram1 regulates DNA damage-induced alternative autophagy |
title_full | Dram1 regulates DNA damage-induced alternative autophagy |
title_fullStr | Dram1 regulates DNA damage-induced alternative autophagy |
title_full_unstemmed | Dram1 regulates DNA damage-induced alternative autophagy |
title_short | Dram1 regulates DNA damage-induced alternative autophagy |
title_sort | dram1 regulates dna damage-induced alternative autophagy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558930/ https://www.ncbi.nlm.nih.gov/pubmed/31225467 http://dx.doi.org/10.15698/cst2018.03.127 |
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