Dram1 regulates DNA damage-induced alternative autophagy

Autophagy is an evolutionarily conserved process that degrades subcellular constituents. Mammalian cells undergo two types of autophagy; Atg5-dependent conventional autophagy and Atg5-independent alternative autophagy, and the molecules required for the latter type of autophagy are largely unknown....

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Autores principales: Nagata, Meruna, Arakawa, Satoko, Yamaguchi, Hirofumi, Torii, Satoru, Endo, Hazuki, Tsujioka, Masatsune, Honda, Shinya, Nishida, Yuya, Konishi, Akimitsu, Shimizu, Shigeomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558930/
https://www.ncbi.nlm.nih.gov/pubmed/31225467
http://dx.doi.org/10.15698/cst2018.03.127
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author Nagata, Meruna
Arakawa, Satoko
Yamaguchi, Hirofumi
Torii, Satoru
Endo, Hazuki
Tsujioka, Masatsune
Honda, Shinya
Nishida, Yuya
Konishi, Akimitsu
Shimizu, Shigeomi
author_facet Nagata, Meruna
Arakawa, Satoko
Yamaguchi, Hirofumi
Torii, Satoru
Endo, Hazuki
Tsujioka, Masatsune
Honda, Shinya
Nishida, Yuya
Konishi, Akimitsu
Shimizu, Shigeomi
author_sort Nagata, Meruna
collection PubMed
description Autophagy is an evolutionarily conserved process that degrades subcellular constituents. Mammalian cells undergo two types of autophagy; Atg5-dependent conventional autophagy and Atg5-independent alternative autophagy, and the molecules required for the latter type of autophagy are largely unknown. In this study, we analyzed the molecular mechanisms of genotoxic stress-induced alternative autophagy, and identified the essential role of p53 and damage-regulated autophagy modulator (Dram1). Dram1 was sufficient to induce alternative autophagy. In the mechanism of alternative autophagy, Dram1 functions in the closure of isolation membranes downstream of p53. These findings indicate that Dram1 plays a pivotal role in genotoxic stress-induced alternative autophagy.
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spelling pubmed-65589302019-06-20 Dram1 regulates DNA damage-induced alternative autophagy Nagata, Meruna Arakawa, Satoko Yamaguchi, Hirofumi Torii, Satoru Endo, Hazuki Tsujioka, Masatsune Honda, Shinya Nishida, Yuya Konishi, Akimitsu Shimizu, Shigeomi Cell Stress Research Article Autophagy is an evolutionarily conserved process that degrades subcellular constituents. Mammalian cells undergo two types of autophagy; Atg5-dependent conventional autophagy and Atg5-independent alternative autophagy, and the molecules required for the latter type of autophagy are largely unknown. In this study, we analyzed the molecular mechanisms of genotoxic stress-induced alternative autophagy, and identified the essential role of p53 and damage-regulated autophagy modulator (Dram1). Dram1 was sufficient to induce alternative autophagy. In the mechanism of alternative autophagy, Dram1 functions in the closure of isolation membranes downstream of p53. These findings indicate that Dram1 plays a pivotal role in genotoxic stress-induced alternative autophagy. Shared Science Publishers OG 2018-03-07 /pmc/articles/PMC6558930/ /pubmed/31225467 http://dx.doi.org/10.15698/cst2018.03.127 Text en Copyright: © 2018 Nagata et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
spellingShingle Research Article
Nagata, Meruna
Arakawa, Satoko
Yamaguchi, Hirofumi
Torii, Satoru
Endo, Hazuki
Tsujioka, Masatsune
Honda, Shinya
Nishida, Yuya
Konishi, Akimitsu
Shimizu, Shigeomi
Dram1 regulates DNA damage-induced alternative autophagy
title Dram1 regulates DNA damage-induced alternative autophagy
title_full Dram1 regulates DNA damage-induced alternative autophagy
title_fullStr Dram1 regulates DNA damage-induced alternative autophagy
title_full_unstemmed Dram1 regulates DNA damage-induced alternative autophagy
title_short Dram1 regulates DNA damage-induced alternative autophagy
title_sort dram1 regulates dna damage-induced alternative autophagy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558930/
https://www.ncbi.nlm.nih.gov/pubmed/31225467
http://dx.doi.org/10.15698/cst2018.03.127
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