New γ-Halo-δ-lactones and δ-Hydroxy-γ-lactones with Strong Cytotoxic Activity

This paper presents the synthesis of [Formula: see text]-halo- [Formula: see text]-lactones, [Formula: see text]-iodo- [Formula: see text]-lactones and [Formula: see text]-hydroxy- [Formula: see text]-lactones from readily available organic substrates such as trans-crotonaldehyde and aryl bromides....

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Autores principales: Kamizela, Angelika, Gawdzik, Barbara, Urbaniak, Mariusz, Lechowicz, Łukasz, Białońska, Agata, Kutniewska, Sylwia Ewa, Gonciarz, Weronika, Chmiela, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572184/
https://www.ncbi.nlm.nih.gov/pubmed/31096674
http://dx.doi.org/10.3390/molecules24101875
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author Kamizela, Angelika
Gawdzik, Barbara
Urbaniak, Mariusz
Lechowicz, Łukasz
Białońska, Agata
Kutniewska, Sylwia Ewa
Gonciarz, Weronika
Chmiela, Magdalena
author_facet Kamizela, Angelika
Gawdzik, Barbara
Urbaniak, Mariusz
Lechowicz, Łukasz
Białońska, Agata
Kutniewska, Sylwia Ewa
Gonciarz, Weronika
Chmiela, Magdalena
author_sort Kamizela, Angelika
collection PubMed
description This paper presents the synthesis of [Formula: see text]-halo- [Formula: see text]-lactones, [Formula: see text]-iodo- [Formula: see text]-lactones and [Formula: see text]-hydroxy- [Formula: see text]-lactones from readily available organic substrates such as trans-crotonaldehyde and aryl bromides. Crystal structure analysis was carried out for lactones that were obtained in crystalline form. All halo- [Formula: see text]-lactones and [Formula: see text]-hydroxy- [Formula: see text]-lactones were highly cytotoxic against gastric cancer AGS cells with [Formula: see text] values in the range of 0.0006–0.0044 mM. Some lactones showed high bactericidal activity against E. coli ATCC 8739 and S. aureus ATCC 65389, which reduced the number of CFU/mL by 70–83% and 87% respectively.
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spelling pubmed-65721842019-06-18 New γ-Halo-δ-lactones and δ-Hydroxy-γ-lactones with Strong Cytotoxic Activity Kamizela, Angelika Gawdzik, Barbara Urbaniak, Mariusz Lechowicz, Łukasz Białońska, Agata Kutniewska, Sylwia Ewa Gonciarz, Weronika Chmiela, Magdalena Molecules Article This paper presents the synthesis of [Formula: see text]-halo- [Formula: see text]-lactones, [Formula: see text]-iodo- [Formula: see text]-lactones and [Formula: see text]-hydroxy- [Formula: see text]-lactones from readily available organic substrates such as trans-crotonaldehyde and aryl bromides. Crystal structure analysis was carried out for lactones that were obtained in crystalline form. All halo- [Formula: see text]-lactones and [Formula: see text]-hydroxy- [Formula: see text]-lactones were highly cytotoxic against gastric cancer AGS cells with [Formula: see text] values in the range of 0.0006–0.0044 mM. Some lactones showed high bactericidal activity against E. coli ATCC 8739 and S. aureus ATCC 65389, which reduced the number of CFU/mL by 70–83% and 87% respectively. MDPI 2019-05-15 /pmc/articles/PMC6572184/ /pubmed/31096674 http://dx.doi.org/10.3390/molecules24101875 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kamizela, Angelika
Gawdzik, Barbara
Urbaniak, Mariusz
Lechowicz, Łukasz
Białońska, Agata
Kutniewska, Sylwia Ewa
Gonciarz, Weronika
Chmiela, Magdalena
New γ-Halo-δ-lactones and δ-Hydroxy-γ-lactones with Strong Cytotoxic Activity
title New γ-Halo-δ-lactones and δ-Hydroxy-γ-lactones with Strong Cytotoxic Activity
title_full New γ-Halo-δ-lactones and δ-Hydroxy-γ-lactones with Strong Cytotoxic Activity
title_fullStr New γ-Halo-δ-lactones and δ-Hydroxy-γ-lactones with Strong Cytotoxic Activity
title_full_unstemmed New γ-Halo-δ-lactones and δ-Hydroxy-γ-lactones with Strong Cytotoxic Activity
title_short New γ-Halo-δ-lactones and δ-Hydroxy-γ-lactones with Strong Cytotoxic Activity
title_sort new γ-halo-δ-lactones and δ-hydroxy-γ-lactones with strong cytotoxic activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572184/
https://www.ncbi.nlm.nih.gov/pubmed/31096674
http://dx.doi.org/10.3390/molecules24101875
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