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Per-sample immunoglobulin germline inference from B cell receptor deep sequencing data

The collection of immunoglobulin genes in an individual’s germline, which gives rise to B cell receptors via recombination, is known to vary significantly across individuals. In humans, for example, each individual has only a fraction of the several hundred known V alleles. Furthermore, the currentl...

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Detalles Bibliográficos
Autores principales: Ralph, Duncan K., Matsen, Frederick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675132/
https://www.ncbi.nlm.nih.gov/pubmed/31329576
http://dx.doi.org/10.1371/journal.pcbi.1007133