Role of Neutral Sphingomyelinase-2 (NSM 2) in the Control of T Cell Plasma Membrane Lipid Composition and Cholesterol Homeostasis

The activity of neutral sphingomyelinase-2 (NSM2) to catalyze the conversion of sphingomyelin (SM) to ceramide and phosphocholine at the cytosolic leaflet of plasma membrane (PM) is important in T cell receptor (TCR) signaling. We recently identified PKCζ as a major NSM2 downstream effector which re...

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Detalles Bibliográficos
Autores principales: Börtlein, Charlene, Schumacher, Fabian, Kleuser, Burkhard, Dölken, Lars, Avota, Elita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803391/
https://www.ncbi.nlm.nih.gov/pubmed/31681760
http://dx.doi.org/10.3389/fcell.2019.00226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803391/
https://www.ncbi.nlm.nih.gov/pubmed/31681760
http://dx.doi.org/10.3389/fcell.2019.00226

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