Multifaceted roles of microRNAs: From motor neuron generation in embryos to degeneration in spinal muscular atrophy

Two crucial questions in neuroscience are how neurons establish individual identity in the developing nervous system and why only specific neuron subtypes are vulnerable to neurodegenerative diseases. In the central nervous system, spinal motor neurons serve as one of the best-characterized cell typ...

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Autores principales: Chen, Tai-Heng, Chen, Jun-An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861003/
https://www.ncbi.nlm.nih.gov/pubmed/31738166
http://dx.doi.org/10.7554/eLife.50848
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author Chen, Tai-Heng
Chen, Jun-An
author_facet Chen, Tai-Heng
Chen, Jun-An
author_sort Chen, Tai-Heng
collection PubMed
description Two crucial questions in neuroscience are how neurons establish individual identity in the developing nervous system and why only specific neuron subtypes are vulnerable to neurodegenerative diseases. In the central nervous system, spinal motor neurons serve as one of the best-characterized cell types for addressing these two questions. In this review, we dissect these questions by evaluating the emerging role of regulatory microRNAs in motor neuron generation in developing embryos and their potential contributions to neurodegenerative diseases such as spinal muscular atrophy (SMA). Given recent promising results from novel microRNA-based medicines, we discuss the potential applications of microRNAs for clinical assessments of SMA disease progression and treatment.
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spelling pubmed-68610032019-11-20 Multifaceted roles of microRNAs: From motor neuron generation in embryos to degeneration in spinal muscular atrophy Chen, Tai-Heng Chen, Jun-An eLife Developmental Biology Two crucial questions in neuroscience are how neurons establish individual identity in the developing nervous system and why only specific neuron subtypes are vulnerable to neurodegenerative diseases. In the central nervous system, spinal motor neurons serve as one of the best-characterized cell types for addressing these two questions. In this review, we dissect these questions by evaluating the emerging role of regulatory microRNAs in motor neuron generation in developing embryos and their potential contributions to neurodegenerative diseases such as spinal muscular atrophy (SMA). Given recent promising results from novel microRNA-based medicines, we discuss the potential applications of microRNAs for clinical assessments of SMA disease progression and treatment. eLife Sciences Publications, Ltd 2019-11-18 /pmc/articles/PMC6861003/ /pubmed/31738166 http://dx.doi.org/10.7554/eLife.50848 Text en © 2019, Chen and Chen http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Developmental Biology
Chen, Tai-Heng
Chen, Jun-An
Multifaceted roles of microRNAs: From motor neuron generation in embryos to degeneration in spinal muscular atrophy
title Multifaceted roles of microRNAs: From motor neuron generation in embryos to degeneration in spinal muscular atrophy
title_full Multifaceted roles of microRNAs: From motor neuron generation in embryos to degeneration in spinal muscular atrophy
title_fullStr Multifaceted roles of microRNAs: From motor neuron generation in embryos to degeneration in spinal muscular atrophy
title_full_unstemmed Multifaceted roles of microRNAs: From motor neuron generation in embryos to degeneration in spinal muscular atrophy
title_short Multifaceted roles of microRNAs: From motor neuron generation in embryos to degeneration in spinal muscular atrophy
title_sort multifaceted roles of micrornas: from motor neuron generation in embryos to degeneration in spinal muscular atrophy
topic Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861003/
https://www.ncbi.nlm.nih.gov/pubmed/31738166
http://dx.doi.org/10.7554/eLife.50848
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