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Flexible, rule-based dose escalation: The cohort-sequence design
Phase I oncology trials seek to acquire preliminary information on the safety of novel treatments. In current practice, most such trials employ rule-based designs that determine whether to escalate the dose using data from the current dose only. The most popular of these, the 3 + 3, is simple and fa...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029255/ https://www.ncbi.nlm.nih.gov/pubmed/32099932 http://dx.doi.org/10.1016/j.conctc.2020.100541 |