Bardoxolone conjugation enables targeted protein degradation of BRD4

Targeted protein degradation (TPD) has emerged as a powerful tool in drug discovery for the perturbation of protein levels using heterobifunctional small molecules. E3 ligase recruiters remain central to this process yet relatively few have been identified relative to the ~ 600 predicted human E3 li...

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Detalles Bibliográficos
Autores principales: Tong, Bingqi, Luo, Mai, Xie, Yi, Spradlin, Jessica N., Tallarico, John A., McKenna, Jeffrey M., Schirle, Markus, Maimone, Thomas J., Nomura, Daniel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511954/
https://www.ncbi.nlm.nih.gov/pubmed/32968148
http://dx.doi.org/10.1038/s41598-020-72491-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511954/
https://www.ncbi.nlm.nih.gov/pubmed/32968148
http://dx.doi.org/10.1038/s41598-020-72491-9

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