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Protein kinase function of pyruvate kinase M2 and cancer

Pyruvate kinase is a terminal enzyme in the glycolytic pathway, where it catalyzes the conversion of phosphoenolpyruvate to pyruvate and production of ATP via substrate level phosphorylation. PKM2 is one of four isoforms of pyruvate kinase and is widely expressed in many types of tumors and associat...

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Autores principales: Chen, Xun, Chen, Shangwu, Yu, Dongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597019/
https://www.ncbi.nlm.nih.gov/pubmed/33292198
http://dx.doi.org/10.1186/s12935-020-01612-1
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author Chen, Xun
Chen, Shangwu
Yu, Dongsheng
author_facet Chen, Xun
Chen, Shangwu
Yu, Dongsheng
author_sort Chen, Xun
collection PubMed
description Pyruvate kinase is a terminal enzyme in the glycolytic pathway, where it catalyzes the conversion of phosphoenolpyruvate to pyruvate and production of ATP via substrate level phosphorylation. PKM2 is one of four isoforms of pyruvate kinase and is widely expressed in many types of tumors and associated with tumorigenesis. In addition to pyruvate kinase activity involving the metabolic pathway, increasing evidence demonstrates that PKM2 exerts a non-metabolic function in cancers. PKM2 has been shown to be translocated into nucleus, where it serves as a protein kinase to phosphorylate various protein targets and contribute to multiple physiopathological processes. We discuss the nuclear localization of PKM2, its protein kinase function and association with cancers, and regulation of PKM2 activity.
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spelling pubmed-75970192020-11-02 Protein kinase function of pyruvate kinase M2 and cancer Chen, Xun Chen, Shangwu Yu, Dongsheng Cancer Cell Int Review Pyruvate kinase is a terminal enzyme in the glycolytic pathway, where it catalyzes the conversion of phosphoenolpyruvate to pyruvate and production of ATP via substrate level phosphorylation. PKM2 is one of four isoforms of pyruvate kinase and is widely expressed in many types of tumors and associated with tumorigenesis. In addition to pyruvate kinase activity involving the metabolic pathway, increasing evidence demonstrates that PKM2 exerts a non-metabolic function in cancers. PKM2 has been shown to be translocated into nucleus, where it serves as a protein kinase to phosphorylate various protein targets and contribute to multiple physiopathological processes. We discuss the nuclear localization of PKM2, its protein kinase function and association with cancers, and regulation of PKM2 activity. BioMed Central 2020-10-29 /pmc/articles/PMC7597019/ /pubmed/33292198 http://dx.doi.org/10.1186/s12935-020-01612-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chen, Xun
Chen, Shangwu
Yu, Dongsheng
Protein kinase function of pyruvate kinase M2 and cancer
title Protein kinase function of pyruvate kinase M2 and cancer
title_full Protein kinase function of pyruvate kinase M2 and cancer
title_fullStr Protein kinase function of pyruvate kinase M2 and cancer
title_full_unstemmed Protein kinase function of pyruvate kinase M2 and cancer
title_short Protein kinase function of pyruvate kinase M2 and cancer
title_sort protein kinase function of pyruvate kinase m2 and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7597019/
https://www.ncbi.nlm.nih.gov/pubmed/33292198
http://dx.doi.org/10.1186/s12935-020-01612-1
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