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Evaluation of neurobiological and antioxidant effects of novel melatonin analogs in mice
Based on the pharmacophore model of melatonin (MT(1)) receptor, we recently synthesized a series of indole derivatives that showed anticonvulsant activity with low neurotoxicity and hepatotoxicity in rodents. In the present study, the three most potent C3-modified derivatives with hydrazine structur...
Autores principales: | Tchekalarova, Jana, Ivanova, Natasha, Nenchovska, Zlatina, Tzoneva, Rumiana, Stoyanova, Tzveta, Uzunova, Veselina, Surcheva, Slavina, Tzonev, Alex, T. Angelova, Violina, Andreeva-Gateva, Pavlina |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783092/ https://www.ncbi.nlm.nih.gov/pubmed/33424250 http://dx.doi.org/10.1016/j.jsps.2020.10.004 |
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