The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3

p53 mutations with single amino acid changes in cancer often lead to dominant oncogenic changes. Here, we have developed a mouse model of gain-of-function (GOF) p53-driven lung cancer utilizing conditionally active LSL p53-R172H and LSL K-Ras-G12D knock-in alleles that can be activated by Cre in lun...

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Detalles Bibliográficos
Autores principales: Vaughan, Catherine A., Singh, Shilpa, Subler, Mark A., Windle, Jolene J., Inoue, Kazushi, Fry, Elizabeth A., Pillappa, Raghavendra, Grossman, Steven R., Windle, Brad, Andrew Yeudall, W., Deb, Swati Palit, Deb, Sumitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846773/
https://www.ncbi.nlm.nih.gov/pubmed/33514736
http://dx.doi.org/10.1038/s41467-021-20928-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846773/
https://www.ncbi.nlm.nih.gov/pubmed/33514736
http://dx.doi.org/10.1038/s41467-021-20928-8

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