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Single-Cell Trajectory Inference Guided Enhancement of Thyroid Maturation In Vitro Using TGF-Beta Inhibition
The thyroid gland regulates metabolism and growth via secretion of thyroid hormones by thyroid follicular cells (TFCs). Loss of TFCs, by cellular dysfunction, autoimmune destruction or surgical resection, underlies hypothyroidism. Recovery of thyroid hormone levels by transplantation of mature TFCs...
Autores principales: | Romitti, Mírian, Eski, Sema Elif, Fonseca, Barbara Faria, Gillotay, Pierre, Singh, Sumeet Pal, Costagliola, Sabine |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202408/ https://www.ncbi.nlm.nih.gov/pubmed/34135860 http://dx.doi.org/10.3389/fendo.2021.657195 |
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