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New homozygous gpt delta transgenic rat strain improves an efficiency of the in vivo mutagenicity assay
BACKGROUND: Gene mutation assays in transgenic rodents are useful tools to investigate in vivo mutagenicity in a target tissue. Using a lambda EG10 transgene containing reporter genes, gpt delta transgenic mice and rats have been developed to detect point mutations and deletions. The transgene is in...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8220708/ https://www.ncbi.nlm.nih.gov/pubmed/34158118 http://dx.doi.org/10.1186/s41021-021-00195-1 |