Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging

Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy. The polyamine pathway is highly conserved from bacteria to mammals and spermidine (prominently found in some kinds of aged cheese, wheat germs, nuts, soybeans, and fermented product...

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Autores principales: Hofer, Sebastian J., Liang, YongTian, Zimmermann, Andreas, Schroeder, Sabrina, Dengjel, Jörn, Kroemer, Guido, Eisenberg, Tobias, Sigrist, Stephan J., Madeo, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386697/
https://www.ncbi.nlm.nih.gov/pubmed/34105442
http://dx.doi.org/10.1080/15548627.2021.1933299
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author Hofer, Sebastian J.
Liang, YongTian
Zimmermann, Andreas
Schroeder, Sabrina
Dengjel, Jörn
Kroemer, Guido
Eisenberg, Tobias
Sigrist, Stephan J.
Madeo, Frank
author_facet Hofer, Sebastian J.
Liang, YongTian
Zimmermann, Andreas
Schroeder, Sabrina
Dengjel, Jörn
Kroemer, Guido
Eisenberg, Tobias
Sigrist, Stephan J.
Madeo, Frank
author_sort Hofer, Sebastian J.
collection PubMed
description Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy. The polyamine pathway is highly conserved from bacteria to mammals and spermidine (prominently found in some kinds of aged cheese, wheat germs, nuts, soybeans, and fermented products thereof, among others) is an intrinsic part of the human diet. Apart from nutrition, spermidine is available to mammalian organisms from intracellular biosynthesis and microbial production in the gut. Importantly, externally supplied spermidine (via drinking water or food) prolongs lifespan, activates autophagy, improves mitochondrial function, and refills polyamine pools that decline during aging in various tissues of model organisms, including mice. In two adjacent studies, we explored how dietary spermidine supplementation enhances eEF5/EIF5A hypusination, cerebral mitochondrial function and cognition in aging Drosophila melanogaster and mice.
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spelling pubmed-83866972021-08-25 Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging Hofer, Sebastian J. Liang, YongTian Zimmermann, Andreas Schroeder, Sabrina Dengjel, Jörn Kroemer, Guido Eisenberg, Tobias Sigrist, Stephan J. Madeo, Frank Autophagy Autophagic Punctum Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy. The polyamine pathway is highly conserved from bacteria to mammals and spermidine (prominently found in some kinds of aged cheese, wheat germs, nuts, soybeans, and fermented products thereof, among others) is an intrinsic part of the human diet. Apart from nutrition, spermidine is available to mammalian organisms from intracellular biosynthesis and microbial production in the gut. Importantly, externally supplied spermidine (via drinking water or food) prolongs lifespan, activates autophagy, improves mitochondrial function, and refills polyamine pools that decline during aging in various tissues of model organisms, including mice. In two adjacent studies, we explored how dietary spermidine supplementation enhances eEF5/EIF5A hypusination, cerebral mitochondrial function and cognition in aging Drosophila melanogaster and mice. Taylor & Francis 2021-06-09 /pmc/articles/PMC8386697/ /pubmed/34105442 http://dx.doi.org/10.1080/15548627.2021.1933299 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Autophagic Punctum
Hofer, Sebastian J.
Liang, YongTian
Zimmermann, Andreas
Schroeder, Sabrina
Dengjel, Jörn
Kroemer, Guido
Eisenberg, Tobias
Sigrist, Stephan J.
Madeo, Frank
Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging
title Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging
title_full Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging
title_fullStr Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging
title_full_unstemmed Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging
title_short Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging
title_sort spermidine-induced hypusination preserves mitochondrial and cognitive function during aging
topic Autophagic Punctum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386697/
https://www.ncbi.nlm.nih.gov/pubmed/34105442
http://dx.doi.org/10.1080/15548627.2021.1933299
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