Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging
Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy. The polyamine pathway is highly conserved from bacteria to mammals and spermidine (prominently found in some kinds of aged cheese, wheat germs, nuts, soybeans, and fermented product...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386697/ https://www.ncbi.nlm.nih.gov/pubmed/34105442 http://dx.doi.org/10.1080/15548627.2021.1933299 |
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author | Hofer, Sebastian J. Liang, YongTian Zimmermann, Andreas Schroeder, Sabrina Dengjel, Jörn Kroemer, Guido Eisenberg, Tobias Sigrist, Stephan J. Madeo, Frank |
author_facet | Hofer, Sebastian J. Liang, YongTian Zimmermann, Andreas Schroeder, Sabrina Dengjel, Jörn Kroemer, Guido Eisenberg, Tobias Sigrist, Stephan J. Madeo, Frank |
author_sort | Hofer, Sebastian J. |
collection | PubMed |
description | Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy. The polyamine pathway is highly conserved from bacteria to mammals and spermidine (prominently found in some kinds of aged cheese, wheat germs, nuts, soybeans, and fermented products thereof, among others) is an intrinsic part of the human diet. Apart from nutrition, spermidine is available to mammalian organisms from intracellular biosynthesis and microbial production in the gut. Importantly, externally supplied spermidine (via drinking water or food) prolongs lifespan, activates autophagy, improves mitochondrial function, and refills polyamine pools that decline during aging in various tissues of model organisms, including mice. In two adjacent studies, we explored how dietary spermidine supplementation enhances eEF5/EIF5A hypusination, cerebral mitochondrial function and cognition in aging Drosophila melanogaster and mice. |
format | Online Article Text |
id | pubmed-8386697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-83866972021-08-25 Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging Hofer, Sebastian J. Liang, YongTian Zimmermann, Andreas Schroeder, Sabrina Dengjel, Jörn Kroemer, Guido Eisenberg, Tobias Sigrist, Stephan J. Madeo, Frank Autophagy Autophagic Punctum Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy. The polyamine pathway is highly conserved from bacteria to mammals and spermidine (prominently found in some kinds of aged cheese, wheat germs, nuts, soybeans, and fermented products thereof, among others) is an intrinsic part of the human diet. Apart from nutrition, spermidine is available to mammalian organisms from intracellular biosynthesis and microbial production in the gut. Importantly, externally supplied spermidine (via drinking water or food) prolongs lifespan, activates autophagy, improves mitochondrial function, and refills polyamine pools that decline during aging in various tissues of model organisms, including mice. In two adjacent studies, we explored how dietary spermidine supplementation enhances eEF5/EIF5A hypusination, cerebral mitochondrial function and cognition in aging Drosophila melanogaster and mice. Taylor & Francis 2021-06-09 /pmc/articles/PMC8386697/ /pubmed/34105442 http://dx.doi.org/10.1080/15548627.2021.1933299 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Autophagic Punctum Hofer, Sebastian J. Liang, YongTian Zimmermann, Andreas Schroeder, Sabrina Dengjel, Jörn Kroemer, Guido Eisenberg, Tobias Sigrist, Stephan J. Madeo, Frank Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging |
title | Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging |
title_full | Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging |
title_fullStr | Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging |
title_full_unstemmed | Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging |
title_short | Spermidine-induced hypusination preserves mitochondrial and cognitive function during aging |
title_sort | spermidine-induced hypusination preserves mitochondrial and cognitive function during aging |
topic | Autophagic Punctum |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386697/ https://www.ncbi.nlm.nih.gov/pubmed/34105442 http://dx.doi.org/10.1080/15548627.2021.1933299 |
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