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Local adenoviral delivery of soluble CD200R-Ig enhances antitumor immunity by inhibiting CD200-β-catenin-driven M2 macrophage
CD200 is known as an immune checkpoint molecule that inhibits innate immune cell activation. Using a head and neck squamous cell carcinoma (HNSCC) model, we sought to determine whether localized delivery of adenovirus-expressing sCD200R1-Ig, the soluble extracellular domain of CD200R1, enhances anti...
Autores principales: | Shin, Seung-Phil, Goh, A-Ra, Ju, Ji-Min, Kang, Hyeon-Gu, Kim, Seok-Jun, Kim, Jong-Kwang, Park, Eun-Jung, Bae, Yong-Soo, Choi, Kyungho, Jung, Yuh-Seog, Lee, Sang-Jin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503857/ https://www.ncbi.nlm.nih.gov/pubmed/34703882 http://dx.doi.org/10.1016/j.omto.2021.09.001 |
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