Regulation of PXR Function by Coactivator and Corepressor Proteins: Ligand Binding Is Just the Beginning

The pregnane X receptor (PXR, NR1I2) is a nuclear receptor which exerts its regulatory function by heterodimerization with the retinoid-X-receptor α (RXRα, NR2B1) and binding to the promoter and enhancer regions of diverse target genes. PXR is involved in the regulation of drug metabolism and excret...

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Detalles Bibliográficos
Autores principales: Rigalli, Juan Pablo, Theile, Dirk, Nilles, Julie, Weiss, Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625645/
https://www.ncbi.nlm.nih.gov/pubmed/34831358
http://dx.doi.org/10.3390/cells10113137