Cargando…
Sex‐related differential susceptibility to ponatinib cardiotoxicity and differential modulation of the Notch1 signalling pathway in a murine model
Ponatinib (PON), a tyrosine kinase inhibitor approved in chronic myeloid leukaemia, has proven cardiovascular toxicity. We assessed mechanisms of sex‐related PON‐induced cardiotoxicity and identified rescue strategies in a murine model. PON+scrambled siRNA‐treated male mice had a higher number of TU...
Autores principales: | Madonna, Rosalinda, Pieragostino, Damiana, Cufaro, Maria Concetta, Del Boccio, Piero, Pucci, Angela, Mattii, Letizia, Doria, Vanessa, Cadeddu Dessalvi, Christian, Zucchi, Riccardo, Mercuro, Giuseppe, De Caterina, Raffaele |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8899159/ https://www.ncbi.nlm.nih.gov/pubmed/35122387 http://dx.doi.org/10.1111/jcmm.17008 |
Ejemplares similares
-
Ponatinib Induces Vascular Toxicity through the Notch-1 Signaling Pathway
por: Madonna, Rosalinda, et al.
Publicado: (2020) -
Connexin 43 and Connexin 26 Involvement in the Ponatinib-Induced Cardiomyopathy: Sex-Related Differences in a Murine Model
por: Madonna, Rosalinda, et al.
Publicado: (2021) -
Metabolomic Perspectives in Antiblastic Cardiotoxicity and Cardioprotection
por: Deidda, Martino, et al.
Publicado: (2019) -
Extracellular Vesicles and Their Potential Use in Monitoring Cancer Progression and Therapy: The Contribution of Proteomics
por: Cufaro, Maria Concetta, et al.
Publicado: (2019) -
A recommended practical approach to the management of anthracycline-based chemotherapy cardiotoxicity: an opinion paper of the working group on drug cardiotoxicity and cardioprotection, Italian Society of Cardiology
por: Spallarossa, Paolo, et al.
Publicado: (2016)